Despite recognition that Alzheimer's disease (AD) is a polygenic and heterogeneous
dementing neurodegenerative disorder, there is continued merit in defining the AD …

The definitive diagnosis of Alzheimer's disease (AD) rests with post-mortem neuropathology
despite the advent of more sensitive scanning and the search for reliable biomarkers. Even …

This report summarizes the consensus recommendations of a panel of neuropathologists
from the United States and Europe to improve the postmortem diagnostic criteria for …

This report summarizes the consensus recommendations of a panel of neuropathologists
from the United States and Europe to improve the postmortem diagnostic criteria for …

Defining criteria for the postmortem diagnosis of Alzheimer's disease (AD) has proven
difficult due to the phenotypical heterogeneity of the disease, the absence of a specific …

The unequivocal diagnosis of Alzheimer disease (AD) rests on histopathological evidence at
brain autopsy or biopsy. Although the histological features of AD are well known, defining …

The provisional criteria proposed in 1985 by Khachaturian et al. emphasized numbers of
plaques and neglected tangles, as did CERAD (Consortium to Establish a Registry for …

The causes of progressive dementia in an elderly patient are legion, and clinical evaluations
to determine the basis of dementia in a patient are costly, labor intensive, and often …

These 2 neuropathological hallmarks have been the cornerstone of neuropathological
diagnosis ever since. However, since a few of these lesions are detected in most individuals …

The lesions of Alzheimer disease (AD) consist of synapse and neuron loss associated with
progressive deposition of amyloid as diffuse and neuritic plaques and accumulating tau …