Development and regulation of dendritic spine synapses

B Calabrese, MS Wilson, S Halpain - Physiology, 2006 - journals.physiology.org
Dendritic spines are small protrusions from neuronal dendrites that form the postsynaptic
component of most excitatory synapses in the brain. They play critical roles in synaptic …

Molecular mechanisms of dendritic spine development and remodeling

IM Ethell, EB Pasquale - Progress in neurobiology, 2005 - Elsevier
Dendritic spines are small protrusions that cover the surface of dendrites and bear the
postsynaptic component of excitatory synapses. Having an enlarged head connected to the …

Dendritic spine geometry: functional implication and regulation

Y Hayashi, AK Majewska - Neuron, 2005 - cell.com
Dendritic spines are tiny protrusions on dendritic shafts where most excitatory synapses are
located. Recent advances in imaging technologies have given us great insight into the …

Dentritic spines: structure, dynamics and regulation

H Hering, M Sheng - Nature Reviews Neuroscience, 2001 - nature.com
Dendritic spines are tiny protrusions that receive excitatory synaptic input and
compartmentalize postsynaptic responses. Heterogeneous in size and shape, and …

Barriers in the brain: resolving dendritic spine morphology and compartmentalization

M Adrian, R Kusters, CJ Wierenga, C Storm… - Frontiers in …, 2014 - frontiersin.org
Dendritic spines are micron-sized protrusions that harbor the majority of excitatory synapses
in the central nervous system. The head of the spine is connected to the dendritic shaft by a …

Dendritic spines as tunable regulators of synaptic signals

J Tønnesen, UV Nägerl - Frontiers in psychiatry, 2016 - frontiersin.org
Neurons are perpetually receiving vast amounts of information in the form of synaptic input
from surrounding cells. The majority of input occurs at thousands of dendritic spines, which …

Dendritic spines: the locus of structural and functional plasticity

C Sala, M Segal - Physiological reviews, 2014 - journals.physiology.org
The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

Microanatomy of dendritic spines: emerging principles of synaptic pathology in psychiatric and neurological disease

TA Blanpied, MD Ehlers - Biological psychiatry, 2004 - Elsevier
Psychiatric and neurologic disorders ranging from mental retardation to addiction are
accompanied by structural and functional alterations of synaptic connections in the brain …

Postsynaptic signaling during plasticity of dendritic spines

H Murakoshi, R Yasuda - Trends in neurosciences, 2012 - cell.com
Dendritic spines, small bulbous postsynaptic compartments emanating from neuronal
dendrites, have been thought to serve as basic units of memory storage. Despite their small …

Dynamics and pathology of dendritic spines

S Halpain, K Spencer, S Graber - Progress in brain research, 2005 - Elsevier
Dendritic spines are key players in information processing in the brain. Changes in spine
shape and wholesale spine turnover provide mechanisms for modifying existing synaptic …