Although abnormal processing of β-amyloid precursor protein (APP) has been implicated in
the pathogenic cascade leading to Alzheimer's disease, the normal function of this protein is …

Compelling evidence from in vivo model systems within the past decade shows that the APP
family of proteins is important for synaptic development and function in the central and …

Biochemical and genetic studies place the amyloid precursor protein (APP) at the center
stage of Alzheimer's disease (AD) pathogenesis. Although mutations in the APP gene lead …

A critical role of the amyloid precursor protein (APP) in Alzheimer's disease (AD)
pathogenesis has been well established. However, the physiological function of APP …

The mechanisms regulating the outgrowth of neurites during development, as well as after
injury, are key to the understanding of the wiring and functioning of the brain under normal …

A Drosophila gene [amyloid protein precursor-like (Appl)] has recently been identified
whose predicted amino acid sequence (APPL) shares extensive homology with the beta …

Amyloid precursor protein (APP), associated with Alzheimer's disease plaques, is known to
be present in synapses of the brain and in the adult neuromuscular junction (NMJ). In the …

The two pathological hallmarks of Alzheimer's disease, amyloid plaques and neurofibrillary
tangles, involve two apparently unrelated proteins, the amyloid precursor protein (APP) and …

The Drosophila Appl gene encodes a transmembrane protein that is expressed exclusively
in neurons. Amino acid comparisons show that APPL protein is a member of the amyloid …

Despite the critical roles of the amyloid precursor protein (APP) in Alzheimer's disease
pathogenesis, its physiological function remains poorly established. Our previous studies …