Nitric oxide regulates metabolism in murine stress erythroid progenitors to promote recovery during inflammatory anemia

B Ruan, Y Chen, S Trimidal, I Koo, F Qian, J Cai… - bioRxiv, 2023 - biorxiv.org
Inflammation skews bone marrow hematopoiesis increasing the production of myeloid
effector cells at the expense of steady-state erythropoiesis. A compensatory stress …

Itaconate promotes the differentiation of murine stress erythroid progenitors by increasing Nrf2 activity

B Ruan, Y Chen, S Trimidal, I Koo, J Cai, J Mcguigan… - bioRxiv, 2023 - biorxiv.org
Steady state erythropoiesis produces new erythrocytes at a constant rate to replace
senescent erythrocytes removed in the spleen and liver. Inflammation caused by infection or …

[HTML][HTML] Nitric Oxide Dependent Metabolism Regulates the Proliferation and Differentiation of Stress Erythroid Progenitors

B Ruan, Y Chen, I Koo, J Cai, J Mcguigan, M Hall… - Blood, 2021 - Elsevier
Infection and tissue damage induce inflammation, which increases myelopoiesis at the
expense of steady state erythropoiesis. Stress erythropoiesis is induced to compensate for …

3184–METABOLIC REGULATION IN STRESS ERYTHROPOIESIS

S Trimidal, B Ruan, R Paulson - Experimental Hematology, 2024 - Elsevier
Anemia of inflammation (AI) is the second most common anemia after iron-deficiency
anemia. It is often comorbid with other diseases such as infections, chronic kidney disease …

3119–NITRIC OXIDE INDUCES A METABOLIC STATE THAT FAVORS PROLIFERATION AND INHIBITS DIFFERENTIATION OF STRESS ERYTHROID …

B Ruan, Y Chen, I Koo, J Cai, J Mcguigan, M Hall… - Experimental …, 2021 - Elsevier
Inflammation alters hematopoiesis, skewing production to generate myeloid effector cells at
the expense of steady state erythropoiesis. To compensate, stress erythropoiesis is induced …

[HTML][HTML] A Shared Signaling Network That Maintains Erythroid Homeostasis By Activating Stress Erythropoiesis Regulates Inflammation: Implications for the Anemia of …

J Fraser, A Dey, S Nettleford, S Hao, L Zhao… - Blood, 2018 - Elsevier
Anemia is a common secondary pathology resulting from inflammatory diseases including
cancer or infection. Its exact prevalence is difficult to determine, yet its contributions to the …

Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation

Y Chen, J Xiang, F Qian, BT Diwakar… - Blood, The Journal …, 2020 - ashpublications.org
Anemic stress induces stress erythropoiesis, which rapidly generates new erythrocytes to
restore tissue oxygenation. Stress erythropoiesis is best understood in mice where it is …

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

LF Bennett, C Liao, MD Quickel, BS Yeoh… - Science …, 2019 - science.org
Inflammation alters bone marrow hematopoiesis to favor the production of innate immune
effector cells at the expense of lymphoid cells and erythrocytes. Furthermore …

Nitric oxide-dependent expansion of erythroid progenitors in a murine model of chronic psychological stress

S Vignjević Petrinović, M Budeč, D Marković… - Histochemistry and Cell …, 2020 - Springer
Anaemia occurs frequently in patients with heart failure and its current treatment lacks clear
targets. Emerging evidence suggests that erythroid progenitor cell expansion is an integral …

3162–IDENTIFYING THE ROLE OF STAT1 SIGNALING IN THE DEVELOPMENT OF THE EARLY STRESS ERYTHROPOIESIS NICHE

AA Shah, R Paulson - Experimental Hematology, 2024 - Elsevier
When steady-state erythropoiesis is inhibited, an extramedullary pathway called stress
erythropoiesis (SE) is initiated to maintain erythroid homeostasis and prevent potentially …