B Ruan, Y Chen, S Trimidal, I Koo, J Cai, J Mcguigan… - bioRxiv, 2023 - biorxiv.org
Steady state erythropoiesis produces new erythrocytes at a constant rate to replace senescent erythrocytes removed in the spleen and liver. Inflammation caused by infection or …
Infection and tissue damage induce inflammation, which increases myelopoiesis at the expense of steady state erythropoiesis. Stress erythropoiesis is induced to compensate for …
S Trimidal, B Ruan, R Paulson - Experimental Hematology, 2024 - Elsevier
Anemia of inflammation (AI) is the second most common anemia after iron-deficiency anemia. It is often comorbid with other diseases such as infections, chronic kidney disease …
Inflammation alters hematopoiesis, skewing production to generate myeloid effector cells at the expense of steady state erythropoiesis. To compensate, stress erythropoiesis is induced …
Anemia is a common secondary pathology resulting from inflammatory diseases including cancer or infection. Its exact prevalence is difficult to determine, yet its contributions to the …
Anemic stress induces stress erythropoiesis, which rapidly generates new erythrocytes to restore tissue oxygenation. Stress erythropoiesis is best understood in mice where it is …
Inflammation alters bone marrow hematopoiesis to favor the production of innate immune effector cells at the expense of lymphoid cells and erythrocytes. Furthermore …
Anaemia occurs frequently in patients with heart failure and its current treatment lacks clear targets. Emerging evidence suggests that erythroid progenitor cell expansion is an integral …
AA Shah, R Paulson - Experimental Hematology, 2024 - Elsevier
When steady-state erythropoiesis is inhibited, an extramedullary pathway called stress erythropoiesis (SE) is initiated to maintain erythroid homeostasis and prevent potentially …