SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility

YR Shen, HY Wang, YC Kuo, SC Shih, CH Hsu… - PLoS …, 2017 - journals.plos.org
Septins are critical for numerous cellular processes through the formation of heteromeric
filaments and rings indicating the importance of structural regulators in septin assembly …

Regulation of septin phosphorylation: SEPT12 phosphorylation in sperm septin assembly

CH Lin, YR Shen, HY Wang, CW Chiang… - …, 2019 - Wiley Online Library
The sperm annulus, a septin‐based ring structure, is important for reproductive physiology. It
is composed of SEPT12‐based septin core complex followed by assembling as octameric …

The role of the septin family in spermiogenesis

YH Lin, YC Kuo, HS Chiang, PL Kuo - Spermatogenesis, 2011 - Taylor & Francis
Septins (full name: Septin; symbol name: SEPT) belong to a family of polymerizing GTP
binding proteins that are required for many cellular functions, including membrane …

SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins

YC Kuo, YR Shen, HI Chen, YH Lin… - Journal of cell …, 2015 - journals.biologists.com
Male infertility has become a worldwide health problem, but the etiologies of most cases are
still unknown. SEPT12, a GTP-binding protein, is involved in male fertility. Two SEPT12 …

CDC42 negatively regulates testis-specific SEPT12 polymerization

CY Huang, YY Wang, YL Chen, MF Chen… - International journal of …, 2018 - mdpi.com
Septin (SEPT) genes encode well-preserved polymerizing GTP-binding cytoskeletal
proteins. The cellular functions of SEPTs consist of mitosis, cytoskeletal remodeling, cell …

The expression level of septin12 is critical for spermiogenesis

YH Lin, YM Lin, YY Wang, IS Yu, YW Lin… - The American journal of …, 2009 - Elsevier
Septins belong to a family of polymerizing GTP-binding proteins that are required for many
cellular functions, such as membrane compartmentalization, vesicular trafficking, mitosis …

SEPTIN12 Genetic Variants Confer Susceptibility to Teratozoospermia

YH Lin, YY Wang, HI Chen, YC Kuo, YW Chiou… - PLoS …, 2012 - journals.plos.org
It is estimated that 10–15% of couples are infertile and male factors account for about half of
these cases. With the advent of intracytoplasmic sperm injection (ICSI), many infertile men …

SEPT12 mutations cause male infertility with defective sperm annulus

YC Kuo, YH Lin, HI Chen, YY Wang, YW Chiou… - Human …, 2012 - Wiley Online Library
Septins are members of the GTPase superfamily, which has been implicated in diverse
cellular functions including cytokinesis and morphogenesis. Septin 12 (SEPT12) is a testis …

[HTML][HTML] SEPT12-microtubule complexes are required for sperm head and tail formation

PL Kuo, HS Chiang, YY Wang, YC Kuo… - International journal of …, 2013 - mdpi.com
The septin gene belongs to a highly conserved family of polymerizing GTP-binding
cytoskeletal proteins. SEPTs perform cytoskeletal remodeling, cell polarity, mitosis, and …

Septin 7 is a centrosomal protein that ensures S phase entry and microtubule nucleation by maintaining the abundance of p150glued

TY Chen, TC Lin, PL Kuo, ZR Chen… - Journal of Cellular …, 2021 - Wiley Online Library
Septins play important roles in regulating development and differentiation. Septin 7 (SEPT7)
is a crucial component in orchestrating the septin core complex into highly ordered …