The non-radical reactive oxygen species, hydrogen peroxide (H 2 O 2), plays a multifaceted
role within the cell. At low concentrations it acts as a signaling molecule promoting cell …

H 2 O 2 has been found to act as a signaling molecule and secondary messenger in many
signal transduction pathways like in insulin signaling, cell proliferation, and apoptosis. There …

The regulatory mechanisms by which hydrogen peroxide (H 2 O 2) modulates the activity of
transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and …

Significance: Decrypting the cellular response to oxidative stress relies on a comprehensive
understanding of the redox signaling pathways stimulated under oxidizing conditions …

A challenge in the redox field is the elucidation of the molecular mechanisms, by which H 2
O 2 mediates signal transduction in cells. This is relevant since redox pathways are …

It is well established that oxidative stress is an important cause of cell damage associated
with the initiation and progression of many diseases. Consequently, all air-living organisms …

Oxidative stress from excess H2O2 activates transcription factors that restore redox balance
and repair oxidative damage. Although many transcription factors are activated by H2O2, it …

Maintenance of redox balance is essential for fundamental physiological processes,
including growth, differentiation, migration, and circadian rhythms. However, the …

Oxidative stress from excess H 2 O 2 activates transcription factors (TFs) that restore redox
balance and repair oxidative damage. Though many TFs are activated by H 2 O 2, it is …

Reactive oxygen species, such as H 2 O 2, can damage cells but also promote fundamental
processes, including growth, differentiation and migration. The mechanisms allowing cells to …