To date, little is known about the pleiotropic genetic variants among depression, cognition,
and memory. The current research aimed to identify the potential pleiotropic single …

Background Depression has been associated with a higher risk of Alzheimer's disease (AD)
in several prospective studies; however, mechanisms underlying this association remain …

Although a genetic basis of depression has been well established in twin studies,
identification of genome-wide significant loci has been difficult. We hypothesized that …

Depression is one of the most frequent psychiatric symptoms observed in people during the
development of Alzheimer's disease (AD). We hypothesized that genetic factors conferring …

Depression is a common and complex psychiatric illness with considerable heritability.
Genome-wide association studies (GWAS) have been conducted among different definitions …

Depressive symptoms are common in older adults and are particularly prevalent in those
with or at elevated risk for dementia. Although the heritability of depression is estimated to …

Depression is a risk factor for the later development of Alzheimer's disease (AD), but
evidence for the genetic relationship is mixed. Assessing depression symptom-specific …

Abstract Major Depressive Disorder (MDD) often is associated with significant cognitive
dysfunction. We conducted a meta-analysis of genome-wide interaction of MDD and …

Depression increases the conversion risk from amnestic mild cognitive impairment to
Alzheimer's disease with unknown mechanisms. We hypothesize that the cumulative …

Background The genetics of depression has been explored in genome-wide association
studies that focused on either major depressive disorder or depressive symptoms with …