Mechanism-Based Inactivation of tRNA-Guanine Transglycosylase from Escherichia coli by
2-Amino-5-(fluoromethyl)pyrrolo[2,3-d]pyr Page 1 Biochemistry 1995, 34, 15539—15544 …

Revised Manuscript Received August 14, 1995® abstract: A series of 5-substituted 2-
aminopyrrolo [2, 3-< i] pyrimidin-4 (3//)-ones have been synthesized in order to study the …

tRNA–guanine transglycosylase (TGT) is a key enzyme in the post-transcriptional
modification of certain tRNAs with the pyrrolopyrimidine base queuine. TGT is required for …

The enzyme tRNA− guanine transglycosylase (TGT, EC 2.4. 2.29) catalyzes a
posttranscriptional transglycosylation reaction involved in the incorporation of the modified …

Abstract tRNA‐Guanine transglycosylase (TGT) plays a key role in the post‐transcriptional
modification of tRNA. It has been linked with the pathogenicity of shigellae, the causative …

The modified RNA base queuine [7-(4, 5-cis-dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-
deazaguanine] is present in tRNA because of a unique base-exchange process catalyzed …

This paper describes the rational design, synthesis, and biological evaluation of a new
generation of inhibitors of the bacterial enzyme tRNA‐guanine transglycosylase (TGT) …

Serine 90 Is Required for Enzymic Activity by tRNA-Guanine Transglycosylase from
Escherichia coli Page 1 Biochemistry 1994, 33, 7041-7046 7041 Serine 90 Is Required for …

Abstract tRNA-guanine transglycosylases (TGTs) are responsible for incorporating 7-
deazaguanine-modified bases into certain tRNAs in eubacteria (preQ 1), eukarya (queuine) …

Abstract tRNA-guanine transglycosylase (TGT) is the enzyme responsible for the post-
transcriptional modification of specific tRNAs (Asn, Asp, His and Tyr) with queuine. In E. coli …