Functional identification and reconstitution of an odorant receptor in single olfactory neurons

K Touhara, S Sengoku, K Inaki… - Proceedings of the …, 1999 - National Acad Sciences
The olfactory system is remarkable in its capacity to discriminate a wide range of odorants
through a series of transduction events initiated in olfactory receptor neurons. Each olfactory …

Molecular bases of odor discrimination: reconstitution of olfactory receptors that recognize overlapping sets of odorants

K Kajiya, K Inaki, M Tanaka, T Haga… - Journal of …, 2001 - Soc Neuroscience
The vertebrate olfactory system discriminates a wide variety of odorants by relaying coded
information from olfactory sensory neurons in the olfactory epithelium to olfactory cortical …

Functional expression of a mammalian odorant receptor

H Zhao, L Ivic, JM Otaki, M Hashimoto, K Mikoshiba… - Science, 1998 - science.org
Candidate mammalian odorant receptors were first cloned some 6 years ago. The
physiological function of these receptors in initiating transduction in olfactory receptor …

A novel multigene family may encode odorant receptors: a molecular basis for odor recognition

L Buck, R Axel - Cell, 1991 - cell.com
The mammalian olfactory system can recognize and discriminate a large number of different
odorant molecules. The detection of chemically distinct odorants presumably results from the …

Odor discrimination by G protein‐coupled olfactory receptors

K Touhara - Microscopy research and technique, 2002 - Wiley Online Library
The vertebrate olfactory system possesses a remarkable capacity to recognize and
discriminate a variety of odorants by sending the coding information from peripheral …

Signaling pathways in odorant detection.

RR Reed - Neuron, 1992 - europepmc.org
The application of molecular genetic techniques has led to the identification of olfactory-
specific proteins that represent each component in a second messenger cascade. Our …

Expression of mRNAs encoding for two different olfactory receptors in a subset of olfactory receptor neurons

NE Rawson, J Eberwine, R Dotson… - Journal of …, 2000 - Wiley Online Library
Evidence has accumulated to support a model for odorant detection in which individual
olfactory receptor neurons (ORNs) express one of a large family of G protein‐coupled …

Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium

R Vassar, J Ngai, R Axel - Cell, 1993 - cell.com
The signal elicited by the interaction of odorous ligands with receptors on olfactory sensory
neurons must be decoded by the brain to determine which of the numerous receptors have …

Origin of basal activity in mammalian olfactory receptor neurons

J Reisert - Journal of General Physiology, 2010 - rupress.org
Mammalian odorant receptors form a large, diverse group of G protein–coupled receptors
that determine the sensitivity and response profile of olfactory receptor neurons. But little is …

An olfactory sensory neuron line, odora, properly targets olfactory proteins and responds to odorants

JR Murrell, DD Hunter - Journal of Neuroscience, 1999 - Soc Neuroscience
The site for interactions between the nervous system and much of the chemical world is in
the olfactory sensory neuron (OSN). Odorant receptor proteins (ORPs) are postulated to …