Nucleolus and nuclear periphery: velcro for heterochromatin

J Padeken, P Heun - Current opinion in cell biology, 2014 - Elsevier
Heterochromatin was first defined by Emil Heitz in 1928 by light microscopy. In the 1950s
electron microscopy studies revealed that heterochromatin preferentially localizes to the …

Close to the edge: Heterochromatin at the nucleolar and nuclear peripheries

A Bizhanova, PD Kaufman - Biochimica et Biophysica Acta (BBA)-Gene …, 2021 - Elsevier
Chromatin is a dynamic structure composed of DNA, RNA, and proteins, regulating storage
and expression of the genetic material in the nucleus. Heterochromatin plays a crucial role …

The nuclear envelope—a scaffold for silencing?

BD Towbin, P Meister, SM Gasser - Current opinion in genetics & …, 2009 - Elsevier
An increasing number of studies indicate that chromosomes are spatially organized in the
interphase nucleus and that some genes tend to occupy characteristic zones of the nuclear …

Mapping nucleolus-associated chromatin interactions using nucleolus Hi-C reveals pattern of heterochromatin interactions

T Peng, Y Hou, H Meng, Y Cao, X Wang, L Jia… - Nature …, 2023 - nature.com
As the largest substructures in the nucleus, nucleoli are the sites of ribosome biogenesis.
Increasing evidence indicates that nucleoli play a key role in the organization of 3D genome …

The shifting shape of genomes: dynamics of heterochromatin interactions at the nuclear lamina

VE Hoskins, K Smith, KL Reddy - Current opinion in genetics & …, 2021 - Elsevier
The nucleus is a highly structured organelle with many chromatin and protein compartments
that partition the genome into regulatory domains. One such a compartment within the …

DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina

JM Zullo, IA Demarco, R Piqué-Regi, DJ Gaffney… - Cell, 2012 - cell.com
A large fraction of the mammalian genome is organized into inactive chromosomal domains
along the nuclear lamina. The mechanism by which these lamina associated domains …

Chromatin at the nuclear periphery and the regulation of genome functions

C Lemaître, WA Bickmore - Histochemistry and cell biology, 2015 - Springer
Chromatin is not randomly organized in the nucleus, and its spatial organization participates
in the regulation of genome functions. However, this spatial organization is also not entirely …

From single genes to entire genomes: the search for a function of nuclear organization

R Pueschel, F Coraggio, P Meister - Development, 2016 - journals.biologists.com
The existence of different domains within the nucleus has been clear from the time, in the
late 1920s, that heterochromatin and euchromatin were discovered. The observation that …

The nuclear lamina as a gene-silencing hub

YY Shevelyov, DI Nurminsky - Current issues in molecular biology, 2012 - mdpi.com
There is accumulating evidence that the nuclear periphery is a transcriptionally repressive
compartment. A surprisingly large fraction of the genome is either in transient or permanent …

Chromatin: linking structure and function in the nucleolus

PC McKeown, PJ Shaw - Chromosoma, 2009 - Springer
The nucleolus is an informative model structure for studying how chromatin-regulated
transcription relates to nuclear organisation. In this review, we describe how chromatin …