ABSTRACT The MexZ–MexX–MexY multidrug efflux system in Pseudomonas aeruginosa
was studied to determine its contribution to aminoglycoside resistance. Amikacin-resistant …

Introduction. Aminoglycoside antibiotics are widely used to treat infections of Pseudomonas
aeruginosa. The MexXY-OprM efflux pump is an important contributor to aminoglycoside …

Simultaneous overexpression of the MexAB-OprM and MexXY efflux systems was
demonstrated by real-time reverse transcription-PCR and immunoblotting experiments for …

Constitutive overexpression of the active efflux system MexXY/OprM is a major cause of
resistance to aminoglycosides, fluoroquinolones, and cefepime in clinical strains of …

To envisage the roles of MexXY-and MexAB-multidrug efflux pumps in the intrinsic multidrug
resistance of wild-type strain Pseudomonas aeruginosa PAO1, we constructed mutants …

The impact of MexXY efflux pump expression on aminoglycoside resistance in clinical
Pseudomonas aeruginosa isolates has been debated. In this study, we found that, in …

The contribution of the MexXY multidrug efflux system to aminoglycoside resistance was
investigated in 18 clinical isolates of Pseudomonas aeruginosa obtained from dairy cows …

In this study, we investigated the roles of active efflux pumps in antibiotic resistance. The
transcription efflux pump genes were analyzed by real-time polymerase chain reaction …

The purpose of this study was to examine expression and regulation of 6 multidrug efflux
systems, including MexAB-OprM, MexCD-OprJ, MexEF-OprN, MexXY, MexJK, and MexVW …

The contribution of efflux pumps to multidrug resistance in 12 Pseudomonas aeruginosa
isolates from various animal sources was assessed. Western immunoblot analyses …