Just over 15 years ago, 2 independent investigative groups reported the B cell agonist
properties of a newly identified member of the tumor necrosis factor (TNF) ligand …

B cells and B-cell/T-cell collaborations are instrumental in the pathophysiology of systemic
lupus erythematosus (SLE). This commentary highlights in particular the newly discovered …

Objective To determine whether systemic lupus erythematosus (SLE) can develop in the
absence of BAFF in an SLE‐prone host. Methods Starting with C57 BL/6 mice that express a …

Objective To determine whether overexpression of BAFF can promote systemic lupus
erythematosus (SLE)–like autoimmunity in mice that are otherwise autoimmune‐resistant …

B-cell activating factor (BAFF), a member of the family of TNF-like cytokines, supports the
survival and differentiation of B cells. The successful development of belimumab, a human …

Objective To determine the necessity for any individual BAFF receptor in the development of
systemic lupus erythematosus (SLE). Methods Bcma‐, Taci‐, and Br3‐null mutations were …

It is widely accepted that B cells play an essential role in the pathogenesis of rheumatoid
arthritis (RA). B cell involvement is well documented in the presence of detectable …

BAFF blockade is efficacious in murine and human SLE. Whereas the attendant reduction in
B cells contributes to the efficacy, it remains unresolved whether a B cell-independent …

Belimumab, a humanized antibody against B‑cell‑activating factor (BaFF, also known as
Blys and tumor necrosis factor ligand superfamily, member 13b) has been hailed as a …

Given the prominent role currently assigned to B lymphocytes in systemic lupus
erythematosus, it is not surprising that the B cell activity factor belonging to the tumor …