Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-кB/IкBα, p38 MAPK, and Bcl-2/Bax signaling

R Wang, H Zhang, Y Wang, F Song, Y Yuan - International …, 2017 - Elsevier
Quercetin, a natural flavonoid, has been used as a nutritional supplement for its anti-
inflammatory and antioxidative properties. Quercetin was reported to exhibit a wide range of …

The flavonoid quercetin ameliorates liver inflammation and fibrosis by regulating hepatic macrophages activation and polarization in mice

X Li, Q Jin, Q Yao, B Xu, L Li, S Zhang… - Frontiers in …, 2018 - frontiersin.org
At present, there are no effective antifibrotic drugs for patients with chronic liver disease;
hence, the development of antifibrotic therapies is urgently needed. Here, we performed an …

Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways

L Wu, Q Zhang, W Mo, J Feng, S Li, J Li, T Liu, S Xu… - Scientific reports, 2017 - nature.com
The aim of this study was to investigate the effect of quercetin on hepatic fibrosis, a
characteristic response to acute or chronic liver injury. Mice were randomized to bile duct …

Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways

X Li, Q Jin, Q Yao, B Xu, Z Li, C Tu - Toxicology letters, 2016 - Elsevier
This study aimed to investigate the effects of quercetin on liver fibrogenesis in mice and to
elucidate the underlying molecular mechanisms. Mice were administered with carbon …

The construction of preclinical evidence for the treatment of liver fibrosis with quercetin: A systematic review and meta‐analysis

X Guo, Y Li, W Wang, L Wang, S Hu… - Phytotherapy …, 2022 - Wiley Online Library
Abstract Quercetin (3, 3′, 4′, 5, 7‐pentahydroxyflavone), a flavonoid, is widely found in
fruits and vegetables and exerts broad‐spectrum pharmacological effects in the liver. Many …

Beneficial effect of quercetin on cholestatic liver injury

SY Lin, YY Wang, WY Chen, YH Chuang… - The Journal of …, 2014 - Elsevier
Bile duct obstruction and subsequent cholestasis are associated with hepatocellular injury,
cholangiocyte proliferation, stellate cell activation, Kupffer cell activation, oxidative stress …

Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro‐fibrogenic/anti‐fibrogenic molecules balance

LD Hernández‐Ortega… - Journal of …, 2012 - Wiley Online Library
Abstract Background and Aim Development of hepatic cirrhosis involves oxidative stress,
inflammation, hepatic stellate cells (HSC) s activation and fibrosis. On the other hand …

The flavonoid quercetin inhibits dimethylnitrosamine‐induced liver damage in rats

ES Lee, HE Lee, JY Shin, S Yoon… - Journal of pharmacy …, 2003 - Wiley Online Library
Quercetin, one of the most abundant flavonoids in human diet has been reported to exhibit a
wide range of pharmacological properties. In this study, we investigated the protective effect …

Quercetin as a protective agent for liver diseases: A comprehensive descriptive review of the molecular mechanism

X Zhao, J Wang, Y Deng, L Liao, M Zhou… - Phytotherapy …, 2021 - Wiley Online Library
Quercetin is the major representative of the flavonoid subgroup of flavones, with good
pharmacological activities for the treatment of liver diseases, including liver steatosis, fatty …

Pien-Tze-Huang ameliorates hepatic fibrosis via suppressing NF-κB pathway and promoting HSC apoptosis

H Zheng, X Wang, Y Zhang, L Chen, L Hua… - Journal of …, 2019 - Elsevier
Abstract Ethnopharmacological relevance Pien Tze Huang (PZH), a Chinese herbal formula,
has various forms of pharmacological activity including anti-inflammation, liver protection …