Sickle cell disease (SCD) is a hereditary disorder that leads to the production of an
abnormal hemoglobin, hemoglobin S (HbS). HbS polymerizes in deoxygenated conditions …

Sickle cell disease (SCD) is an hereditary disorder characterized by the production of an
abnormal hemoglobin called hemoglobin S (HbS). HbS may polymerize in deoxygenated …

Sickle cell disease (SCD) is a monogenetic disorder caused by a mutation in the β-globin
gene HBB leading to polymerization of red blood cells causing damage to cell membranes …

Introduction In sickle cell disease (SCD), hemoglobin S (HbS) red blood cells (RBCs) are
characteristically deformed and inflexible. Often breaking down in the circulation, they …

THE SICKLE CELL diseases (SCD) are inherited disorders of hemoglobin (Hb) structure
and synthesis, and include homozygous sickle cell anemia (Hb SS), sickle-C disease (Hb …

Clinicians, scientists and lay people alike grasp the concept that sickle-shaped cells flow
poorly in the circulation. Red cell stiffness is the basis of sickle cell vaso-occlusion, but …

Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by polymerization
of hemoglobin S upon deoxygenation that results in the formation of rigid sickled-shaped red …

Sickle cell disease has been very well characterized as a single amino acid molecular
disorder of hemoglobin leading to its pathological polymerization, with resulting red cell …

Sickle cell disease (SCD) is a genetic disease caused by a single mutation in the β-globin
gene, leading to the production of an abnormal hemoglobin called hemoglobin S (HbS) …

Sickle cell disease is an inherited disorder of hemoglobin (Hb) synthesis, caused by a single
nucleotide substitution (GTG> GAG) at the sixth codon of the β-globin gene, leading to the …