The naked DNA inside the nucleus interacts with proteins and RNAs forming a higher order
chromatin structure to spatially and temporally control transcription in eukaryotic cells. The …

The organization and dynamics of chromatin fiber play crucial roles in regulating DNA
accessibility for gene expression. Here we combine cryoelectron tomography (cryo-ET), sub …

Chromatin is spatially organized in a hierarchical manner by virtue of single nucleosomes
condensing into higher order chromatin structures, conferring various mechanical properties …

The structure of chromatin plays pivotal roles in regulating gene transcription, DNA
replication and repair, and chromosome segregation. This structure, however, remains …

Genomic DNA is hierarchically packaged into chromatin in eukaryotes. As a central‐level
chromatin structure between nucleosomal arrays and higher order organizations, 30 nm …

Highlights•Cryo-electro microscopy reveals the native conformation of chromatin fiber both
in vitro and in situ.•Presence of linker histone and ionic conditions determines the level of …

The hierarchical packaging of eukaryotic chromatin plays a central role in transcriptional
regulation and other DNA-related biological processes. Here, we report the 11-angstrom …

The presence and folding pattern of chromatin in eukaryotic cells remain elusive and
controversial. In this study, we prepared ultra-thin sections of Hela cells with three different …

Chromatin is a dynamic molecular complex composed of DNA and proteins that package the
DNA in the nucleus of eukaryotic cells. The basic structural unit of chromatin is the …

Eukaryotic genomes must be folded and compacted to fit within the restricted volume of the
nucleus. According to the current paradigm, strings of nucleosomes, termed 10nm chromatin …