Regulatory T cell-mediated dominant tolerance has been demonstrated to play an important
role in the prevention of autoimmunity. Here, we present data arguing that the forkhead …

The random generation of antigen receptors in developing lymphocytes results in a
considerable risk of autoimmunity. Regulatory T cells (Treg cells) act in a dominant, trans …

The immune system has evolved mechanisms to recognize and eliminate threats, as well as
to protect against self-destruction. Tolerance to self-antigens is generated through two …

Abstract CD4+ CD25+ regulatory T cells are essential for the active suppression of
autoimmunity. Here we report that the forkhead transcription factor Foxp3 is specifically …

Foxp3, an X chromosome–encoded forkhead transcription factor family member, is
indispensable for the differentiation of regulatory T cells. These cells have a vital role in …

In the periphery, tolerance to self antigens is mainly mediated by the CD4+ CD25+ FOXP3+
subset of regulatory T cells, which can suppress the activity of autoreactive T cells that have …

Regulatory T cells that express the Foxp3 transcription factor play important roles in
preventing autoimmune diseases. Although several studies have demonstrated that the lack …

Regulatory T cells are capable of suppressing deleterious immune responses against self-or
non-self-antigens. Their essential role in tolerance and immune regulation has been …

Early studies of mice subjected to neonatal thymectomy and analyses of adoptive T‐cell
transfer into lymphopenic hosts led to the identification of a specialized subset of regulatory …

Differing from the mouse Foxp3 gene that encodes only one protein product, human FOXP3
encodes two major isoforms through alternative splicing—a longer isoform (FOXP3 FL) …