Extracellular Vesicles Generated by Mesenchymal Stem Cells in Stirred Suspension Bioreactors Promote Angiogenesis in Human-Brain-Derived Endothelial Cells

J Phelps, DA Hart, AP Mitha, NA Duncan… - International Journal of …, 2024 - mdpi.com
Interrupted blood flow in the brain due to ischemic injuries such as ischemic stroke or
traumatic brain injury results in irreversible brain damage, leading to cognitive impairment …

Physiological oxygen conditions enhance the angiogenic properties of extracellular vesicles from human mesenchymal stem cells

J Phelps, DA Hart, AP Mitha, NA Duncan… - Stem cell research & …, 2023 - Springer
Background Following an ischemic injury to the brain, the induction of angiogenesis is
critical to neurological recovery. The angiogenic benefits of mesenchymal stem cells (MSCs) …

Mesenchymal stem cell-derived extracellular vesicle therapy for stroke: challenges and progress

OY Bang, EH Kim - Frontiers in neurology, 2019 - frontiersin.org
Stroke is the leading cause of physical disability among adults. Stem cells such as
mesenchymal stem cells (MSCs) secrete a variety of bioactive substances, including trophic …

Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke

Y Li, Q Cheng, G Hu, T Deng… - Experimental and …, 2018 - spandidos-publications.com
A stroke is a focal cerebral insult that frequently causes severe neurological deficit and
mortality. Recent studies have demonstrated that multipotent mesenchymal stromal cells …

Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and …

J Gregorius, C Wang, O Stambouli, T Hussner… - Basic research in …, 2021 - Springer
Obtained from the right cell-type, mesenchymal stromal cell (MSC)-derived small
extracellular vesicles (sEVs) promote stroke recovery. Within this process, microvascular …

Application of mesenchymal stem cell-derived extracellular vesicles for stroke: biodistribution and microRNA study

GJ Moon, JH Sung, DH Kim, EH Kim, YH Cho… - Translational stroke …, 2019 - Springer
Mesenchymal stem cells (MSCs) exert their therapeutic capability through a variety of
bioactive substances, including trophic factors, microRNAs, and extracellular vesicles (EVs) …

Hypoxia Conditioned Mesenchymal Stem Cell-Derived Extracellular Vesicles Induce Increased Vascular Tube Formation in vitro

C Almeria, R Weiss, M Roy, C Tripisciano… - … in Bioengineering and …, 2019 - frontiersin.org
Mesenchymal stem/stromal cells (MSCs) display a variety of therapeutically relevant effects,
such as the induction of angiogenesis, particularly under hypoxic conditions. It is generally …

Mesenchymal stem cell derived extracellular vesicles for repairing the neurovascular unit after ischemic stroke

C Davis, SI Savitz, N Satani - Cells, 2021 - mdpi.com
Ischemic stroke is a debilitating disease and one of the leading causes of long-term
disability. During the early phase after ischemic stroke, the blood-brain barrier (BBB) exhibits …

Impact of cell culture parameters on production and vascularization bioactivity of mesenchymal stem cell‐derived extracellular vesicles

DB Patel, KM Gray, Y Santharam… - Bioengineering & …, 2017 - Wiley Online Library
Mesenchymal stem cell (MSC)‐derived extracellular vesicles (EVs) have emerged as
potential therapeutic agents for numerous applications. EVs offer potential advantages over …

[HTML][HTML] Hollow fiber bioreactor allows sustained production of immortalized mesenchymal stromal cell-derived extracellular vesicles

SG Garcia, M Sanroque-Muñoz… - Extracellular Vesicles …, 2024 - oaepublish.com
Aim: Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) have been
reported to hold great potential as cell-free therapies due to their low immunogenicity and …