There has been considerable in vivo evidence that chemokine receptor CXCR4 and its
endogenous ligand CXCL12 modulate some important physiological and …

CXC chemokine receptor type 4 (CXCR4) is a member of the G protein-coupled receptors
(GPCRs) superfamily and is specific for CXC chemokine ligand 12 (CXCL12, also known as …

Although chemokines are well established to function in immunity and endothelial cell
activation and proliferation, a rapidly growing literature suggests that CXC Chemokine …

Metastasis is the main cause of death in cancer patients; there is currently no effective
treatment for cancer metastasis. This is primarily due to our insufficient understanding of the …

The CXCR4/CXCL12 axis plays a role in cancer metastases, stem cell mobilization and
chemosensitization. Proof of concept for efficient CXCR4 inhibition has been demonstrated …

Chemokines are a class of small cytokines or signaling proteins that are secreted by cells.
Owing to their ability to induce directional chemotaxis of nearby responding cells, they are …

Under physiological conditions, CXCL12 modulates cell proliferation, survival,
angiogenesis, and migration mainly through CXCR4. Interestingly, the newly discovered …

The majority of current cancer therapies focus on a primary tumor approach. However, it is
metastases that cause the majority of cancer deaths. The metastatic process has been …

Chemokine ligand 11 is a member of the CXC chemokine family and exerts its biological
function mainly through binding to CXCR3 and CXCR7. The CXCL11 gene is ubiquitously …

Abstract Chemokine receptor 4 (CXCR4) is a subtype receptor protein of the GPCR family
with a seven-transmembrane structure widely distributed in human tissues. CXCR4 is …