Sickle cell disease is caused by Mutations in the HBB gene. Hemoglobin consists of four
protein subunits, typically, two subunits called alpha-globin and two subunits called beta …

Sickle cell Disease (SCD) is a group of genetic disease commonly seen in United States
and three countries of the world. The term disease is applied to this condition because the …

Sickle cell is a genetic or hereditary disorder, in which red blood cells (RBC) becomes sickle
(oval) shape due to the deficiency of oxygen in blood. Sickle cell is of two different types ie …

Sickle cell disorder is a group of diseases caused by a point mutation at sixth position in
beta globin chain, valine substituting glutamic acid due to which in deoxygenated state …

Background: Sickle cell disease hemoglobinopathy gets inherited in autosomal recessive
pattern. In sickle cell disease substitution of amino acid valine for glutamic acid at the sixth …

Background: Sickle cell disorders are structural hemoglobinopathies, rendering red blood
cells sickle shaped, less deformable and sticky leading to microvascular vaso-occlusion and …

Background: The inherited disorders of hemoglobin are responsible for an extremely
complex series of clinical phenotypes. Sickle cell anemia and thalassemia can cause …

Background: Sickle cell anaemia is a major genetic disease in India that presents major
challenges to our health care systems. Aim and Objective: The aim of this study was to …

Abstract Background of Study: Sickle cell anemic patients show diverse clinical symptoms
with varied complications influenced by genetic, environmental and socioeconomic factors …

Present study deals with current scenario of sickle cell anemia from Dhulia district of
Maharashtra state (India). Dhulia district is one of the tribal district, situated in North-western …