Exposure of isolated guinea-pig ventricular myocytes to the uncharged oximes 2, 3
butanedionemonoxine (BDM) and norPAM (but not by the charged PAM) results in a dose …

Objective: The aim was to assess the effects of various antiarrhythmic drugs on 2, 4-
dinitrophenol (DNP) induced outward current (IDNP), presumably the ATP sensitive K+ …

A chemical phosphatase, butanedione monoxime (BDM, at 12–20 mM), reduced open
probability (P 0) of single cardiac L-type Ca 2+ channels in cellattached patches from guinea …

1. Application of the phosphatase inhibitors okadaic acid (OA) and microcystin (MC) to frog
cardiomyocytes caused large increases in L‐type calcium current (ICa) in the absence of …

The effects of N-acetylprocainamide (NAPA) and sotalol on membrane current systems of
guinea-pig ventricular myocytes were examined and compared with those of quinidine using …

The effects of a protein phosphatase inhibitor, okadaic acid (OA), were studied on
membrane currents of isolated myocytes from guinea-pig cardiac ventricle. The whole-cell …

We studied the effects of adenosine and isoproterenol on membrane currents of isolated
bovine and guinea pig ventricular myocytes with a two-microelectrode voltage clamp …

1. An increase in the rate of stimulation induces an augmentation of L‐type Ca2+ currents
(ICa) and concomitant slowing of current decay in rat ventricular cells. This facilitation is …

The calcium current (I Ca) in the heart is increased by phosphorylation of a protein which is
part of, or close to, the Ca channel. The phosphorylation is catalysed by cAMP-dependent …

Studies have suggested that integration of kinase and phosphatase activities maintains the
steady‐state L‐type Ca2+ current in ventricular myocytes, a balance disrupted in failing …