Pharmacoinformatics approaches are widely used in the field of drug discovery as it saves
time, investment and animal sacrifice. In the present study, pharmacore-based virtual …

A combined ligand and structure-based drug design approach provides a synergistic
advantage over either methods performed individually. Present work bestows a good …

The HIV-1 protease has proven to be a crucial component of the HIV replication machinery
and a reliable target for anti-HIV drug discovery. In this study, we applied an optimized …

The human immunodeficiency virus type 1 (HIV-1) has continued to be a global concern.
With the new HIV incidence, the emergence of multi-drug resistance and the untoward side …

Human immunodeficiency virus type 1 protease (HIV-1 PR) inhibitors have been used as
possible therapeutic agents for HIV-1 infection in clinical study. Most of the HIV therapy …

A model for the classification of 70 HIV-1 protease crystal structure binding pockets to one of
its complexed FDA approved protease inhibitors utilizing Random Forest has been …

The HIV protease enzyme (maturation enzyme) is one of the most promising therapeutic
targets for the treatment of AIDS. Due to the mutation in the virus, there is always room for …

In this paper, two 3‐dimensional quantitative structure‐activity relationship models for 60
human immunodeficiency virus (HIV)‐1 protease inhibitors were established using random …

Human immunodeficiency virus infection/acquired immunodeficiency syndrome (HIV/AIDS)
is a disease pertained to the human immune system. Given its crucial role in viral replication …

A number of anti-retroviral drugs are being used for treating Human Immunodeficiency Virus
(HIV) infection. Due to emergence of drug resistant strains, there is a constant quest to …