Blood–brain barrier dysfunction in status epileptics: Mechanisms and role in epileptogenesis

E Swissa, Y Serlin, U Vazana, O Prager, A Friedman - Epilepsy & Behavior, 2019 - Elsevier
… epilepticus, and in epileptogenic brain regions, may last for months. Blood–brain barrier
dysfunction was shown to have a role in astroglial dysfunction, neuroinflammation, increasing …

Role of blood-brain barrier dysfunction in epileptogenesis

B INSULTS - Jasper's basic mechanisms of the epilepsies, 2012 - books.google.com
… communication in epileptogenesis, 20 supported by the … for the involvement of BBB dysfunction
in epileptogenesis has … , BBB dysfunction does not seem to induce epileptogenesis by …

Mechanisms underlying blood–brain barrier dysfunction in brain pathology and epileptogenesis: role of astroglia

R Kovács, U Heinemann, C Steinhäuser - Epilepsia, 2012 - Wiley Online Library
… bloodâ•fibrain barrier dysfunction in brain pathology and epileptogenesis: Role of astroglia
… function might critically contribute to epileptogenesis. Therefore, astrocytes represent a …

Blood–brain barrier dysfunction–induced inflammatory signaling in brain pathology and epileptogenesis

SY Kim, M Buckwalter, H Soreq, A Vezzani… - Epilepsia, 2012 - Wiley Online Library
… In this review we examine the role of BBB and inflammatory responses, in particular
activation of transforming grown factor b (TGFb) signaling, in epilepsy, stroke, and Parkinson’s …

Blood‐brain barrier dysfunction in epileptogenesis of the temporal lobe

I Weissberg, A Reichert, U Heinemann… - Epilepsy research …, 2011 - Wiley Online Library
… The frequent findings of BBB dysfunction after brain insults … for a direct role of BBB dysfunction
in epileptogenesis [33]. … for the involvement of BBB dysfunction in epileptogenesis was …

Structural, molecular, and functional alterations of the blood-brain barrier during epileptogenesis and epilepsy: a cause, consequence, or both?

W Löscher, A Friedman - International journal of molecular sciences, 2020 - mdpi.com
… The blood–brain barrier (BBB) is a dynamic and complex barrier essential for the normal
function of the central nervous system (CNS). The existence of a physical interface between the …

Blood–brain barrier dysfunction and epilepsy: pathophysiologic role and therapeutic approaches

N Marchi, T Granata, C Ghosh, D Janigro - Epilepsia, 2012 - Wiley Online Library
… In conclusion, human studies suggestive of a role of BBB dysfunction in seizure disorders are
… These findings are in agreement with a role of BBB damage in epileptogenesis and in the …

Blood‐brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy

UWE Heinemann, D Kaufer, A Friedman - Glia, 2012 - Wiley Online Library
dysfunctional blood-brain barrier (BBB) might underlie such a shift in reorganizational
balance towards epileptogenesis … , point to a potential role of glia in epileptogenesis. It is thus …

Role of blood–brain barrier in temporal lobe epilepsy and pharmacoresistance

EA Van Vliet, E Aronica, JA Gorter - Neuroscience, 2014 - Elsevier
… In the following paragraphs we will discuss changes of these specific functions in relation
to seizures, epileptogenesis and epilepsy. Dysfunction of the physical barrier Adjacent brain

Imaging blood–brain barrier dysfunction as a biomarker for epileptogenesis

G Bar-Klein, S Lublinsky, L Kamintsky, I Noyman… - Brain, 2017 - academic.oup.com
… blood–brain barrier dysfunction and neuroinflammation. … anti-epileptogenic interventions
were used; isoflurane anaesthesia and losartan. Our results show that early blood–brain barrier