… Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological … and
play an important role in health and disease. In this decade, interleukin-1 family members have …

… antagonist and soluble interleukin-1 receptors are specific inhibitors of interleukin-1, any …
indicate a role for interleukin-1 in that disease. In fact, administering interleukin-1-receptor …

… IL-1 activates B-cells and contributes to formation of antibody. The first experiments to show
the critical role for IL-1 in B-cell activation were performed with anti-IL-1 (57). Adding this …

… This review is concerned with the role of the mononuclear phagocyte product interleukin-l
(lL-I) as a primary mediator of host responses to infections. It is not claimed, however, that IL-l …

… IL-1β is the most studied member of the IL-1 family because of its role in mediating
autoinflammatory diseases. Although the TLR and IL-1 families evolved to assist in host defense …

… properties of IL 1 have stimulated interest in a role for IL 1 in the pathogenesis …
emerges in understanding the role of IL 1 for the survival of the host: the molecule functions …

▪ Abstract The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that
binds to IL-1 receptors but does not induce any intracellular response. Two structural variants …

… which is the cytokine interleukin 1 (IL-1). Recent … role of IL-1 as a costimulator for murine
Thl and Th2 clones. Our results show that only Th2 cells express high-affinity receptors for IL-1 …

… By specifically blocking IL-1, we have learned a great deal about the role of this cytokine in
inflammation, but equally important, reducing IL-1 activity has lifted the burden of disease for …

… role for IL-1 in inflammatory atherogenesis is also predicted. To date, four potent inhibitors
of IL-1 are … , but also helped improve our understanding of the role of IL-1 in human disease. …