SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death

J Oh, WH Cho, E Barcelon, KH Kim, J Hong, SJ Lee - Scientific reports, 2022 - nature.com
… We explored the possibility that the brain-infiltrating SARS-CoV-2 spike … behavioral study
showed that administration of SARS-CoV-2 spike protein S1 subunit (S1 protein) to mouse

Prenatal SARS-CoV-2 infection results in neurodevelopmental and behavioral outcomes in mice

CL McMahon, EM Hurley, AM Perez, M Estrada… - JCI …, 2024 - Am Soc Clin Investig
… -related behaviors, such as … mice infected in utero with SARS-CoV-2 displayed 234
developmental deficits such as slowed growth and lower weight in adulthood, as well as behavioral

SARS-CoV-2 envelope protein triggers depression-like behaviors and dysosmia via TLR2-mediated neuroinflammation in mice

W Su, J Ju, M Gu, X Wang, S Liu, J Yu, D Mu - Journal of …, 2023 - Springer
… -like behaviors and olfactory disorder in mice (Fig. 7D–G). However, the astrocytes inhibition
by LAA failed to recover the depression-like behaviors and olfactory disorder in mice at our …

SARS-CoV-2 infection in the mouse olfactory system

Q Ye, J Zhou, Q He, RT Li, G Yang, Y Zhang, SJ Wu… - Cell discovery, 2021 - nature.com
mouse model to demonstrate that SARS-CoV-2 … SARS-CoV-2 infection is the cause of
olfactory dysfunction and anosmia in COVID-19 patients 5,6,22,23 . SARS-CoV-2-infected mice

Sex-specific microglial activation and SARS-CoV-2 receptor expression induced by chronic unpredictable stress

L Yan, M Jayaram, K Chithanathan… - Frontiers in Cellular …, 2021 - frontiersin.org
… of SARS-CoV2 viral receptors. We observed that female mice showed depressive-like behavior
… of the SARS-CoV-2 receptors in the normal mouse brain using the ISH data in the Allen …

Emerging role of kinin B1 receptor in persistent neuroinflammation and neuropsychiatric symptoms in mice following recovery from SARS-CoV-2 infection

S Sriramula, D Theobald, RU Parekh, SM Akula… - Cells, 2023 - mdpi.com
… the behavior of mice that had recovered from a mild SARS-CoV-2 … SARS-CoV-2 infection
enhanced anxiety-related behavior in the zero maze and attenuated exploratory behavior

Mouse models for the study of SARS-CoV-2 infection

AC Knight, SA Montgomery, CA Fletcher… - Comparative …, 2021 - ingentaconnect.com
… -2 infection of the CNS and the potential long-term effects on behavior and neurologic
health… Virus was also detected in the brains of these mice, with the S protein of SARSCoV-2 …

Non-neutralizing antibodies to SARS-Cov-2-related linear epitopes induce psychotic-like behavior in mice

J Xu, H Wei, P You, J Sui, J Xiu, W Zhu… - Frontiers in Molecular …, 2023 - frontiersin.org
… we observed a psychomotor-like behavioral phenotype with defective sensorimotor gating
mice. Transcriptome profiling showed that up-regulated genes in S1-111-immunized mice

SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice

FL Fontes-Dantas, GG Fernandes, EG Gutman… - Cell reports, 2023 - cell.com
… Evidence suggests that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Spike … Here, we demonstrate that brain infusion of Spike protein in mice has a late impact on …

The spatial and cell-type distribution of SARS-CoV-2 receptor ACE2 in the human and mouse brains

R Chen, K Wang, J Yu, D Howard, L French… - Frontiers in …, 2021 - frontiersin.org
… Though the infection of SARS-COV in the brain was reported … map of Ace2 in the mouse
brain was similar to that in human. … mouse brains, which supports the hypothesis that SARS-CoV