Repurposing of drugs targeting the cytokine storm induced by SARSCoV‐2

WH Ng, PCH Tang, S Mahalingam… - British Journal of …, 2023 - Wiley Online Library
… Anti-cytokine drugs have been used extensively to … SARS-CoV-2-induced ARDS, in
which the cytokine storm plays an immunopathological role. This minireview includes anti-cytokine

Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment

M Soy, G Keser, P Atagündüz, F Tabak… - Clinical …, 2020 - Springer
… Recently, Wenzhonget al. claimed that antimalarials might block the binding of the SARS
Cov-2 virus to porphyrins and thus prevent the entering of the virus to the cell [8]. Finally, they …

Excitotoxicity (immunoexcitotoxicity) as a critical component of the cytokine storm reaction in pulmonary viral infections, including SARS-CoV-2

RL Blaylock - International Journal of Vaccine Theory, Practice, and …, 2021 - ijvtpr.com
cytokines, by themselves, may not be sufficient to cause the pathological damage that we
see in cases of cytokine storm is … cytokines and chemokines is an early event in the cytokine

A putative role of de-mono-ADP-ribosylation of STAT1 by the SARS-CoV-2 Nsp3 protein in the cytokine storm syndrome of COVID-19

JM Claverie - Viruses, 2020 - mdpi.com
coronavirus strains responsible for the previous epidemics (SARS-CoV and MERS-CoV). The
… STAT1 by the SARS-CoV-2 nsp3 as a putative cause of the cytokine storm observed in the …

[HTML][HTML] Hazards of the cytokine storm and cytokine-targeted therapy in patients with COVID-19

M Quirch, J Lee, S Rehman - Journal of medical Internet research, 2020 - jmir.org
… of morbidity and mortality in SARS-CoV-2, but … cytokine storm response in SARS-CoV-2
and to explore the early treatment options for patients who are critically ill with the coronavirus

High-dose intravenous vitamin C may help in cytokine storm in severe SARS-CoV-2 infection

AF de Melo, M Homem-de-Mello - Critical Care, 2020 - Springer
SARS-CoV-2 remains unclear. The severity of the disease is probably linked to the “cytokine
storm” … the recovery of complicated cases of cytokine storm associated to the SARS-CoV-2. …

Cytokine drizzle—the rationale for abandoning “cytokine storm

AE Stolarski, J Kim, Q Zhang, DG Remick - Shock, 2021 - journals.lww.com
… early investigators to suspect a “cytokine storm” resulting in an unregulated inflammatory …
by SARS CoV-2. The threshold of blood cytokines necessary to qualify as a “cytokine storm” …

Surviving the storm: cytokine biosignature in SARS-CoV-2 severity prediction

R Ahmad, M Haque - Vaccines, 2022 - mdpi.com
… of SARS-CoV-2 induced cytokine storm … of SARS-CoV-2 infection and cytokine storm. There
is the involvement of many more cytokines in the COVID-19 infection-related cytokine storm

Cytokine Storm and its Implication in Coronavirus disease 2019 (COVID-19)

C Datta, A Bhattacharjee - Journal of …, 2020 - immunologyresearchjournal.com
… However, previously published article reported that severe infections caused by SARS
coronavirus may be associated with low levels of IFN production 17 . Therefore, this pathobiologic …

Nanocurcumin potently inhibits SARS-CoV-2 spike protein-induced cytokine storm by deactivation of MAPK/NF-κB signaling in epithelial cells

VK Sharma, Prateeksha, SP Singh… - ACS Applied Bio …, 2022 - ACS Publications
… We prepared the organic NPs of CUR using polysaccharide-rich fraction of turmeric rhizome
in this study, which inhibited the cytokine storm induced by human CoV2-SP in liver Huh7.5 …