Keloids are defined as overgrowths of scar tissue resulting from abnormal wound healing.
They are characterized by excessive dermal deposition of thick, hyalinized collagen bundles
resulting from an imbalance between the production and degradation of extracellular matrix
(ECM) components. Matrix metalloproteinases (MMPs) and tissue inhibitors of
metalloproteinases (TIMPs) are two important regulators of ECM degradation and
remodeling. To evaluate the role played by knockdown of TIMPs in keloid formation, we …

CiNii 博士論文 - siRNA knockdown of tissue inhibitor of metalloproteinase-1 in keloid
fibroblasts leads to degradation of collagen type Ⅰ … siRNA knockdown of tissue inhibitor
of metalloproteinase-1 in keloid fibroblasts leads to degradation of collagen type Ⅰ ヒト
ケロイド由来線維芽細胞におけるTIMP-1 siRNAのコラーゲン分解効果 … ヒトケロイド由来線維芽
細胞におけるTIMP-1 siRNAのコラーゲン分解効果 …