Is a “cytokine storm” relevant to COVID-19?

P Sinha, MA Matthay, CS Calfee - JAMA internal medicine, 2020 - jamanetwork.com
Cytokine storm implies that the levels of released cytokines are injurious to host cells.
Distinguishing … To add further complexity, most mediators implicated in cytokine storm demonstrate …

[HTML][HTML] Stem cell therapy in COVID-19: Pooled evidence from SARS-CoV-2, SARS-CoV, MERS-CoV and ARDS: A systematic review

S Mahendiratta, S Bansal, P Sarma, H Kumar… - Biomedicine & …, 2021 - Elsevier
… Again, from pathophysiologic point of view, all the three viruses are similar to a greater
extent with occurrence of cytokine storm and ARDS being the major pathological hallmark in all …

Stem cell transplantation therapy: a potential method for treating cytokine storm syndromes induced by COVID-19

HC Wang, X Wang, X Long - Cell Transplantation, 2020 - journals.sagepub.com
… It still lacks effective methods of preventing and reversing the cytokine storm. … stem cell
transplantation therapy could not only prevent the immune system from releasing cytokine storm

Molecular mechanisms of multi-organ failure in COVID-19 and potential of stem cell therapy

A Bhalerao, S Raut, B Noorani, S Mancuso, L Cucullo - Cells, 2021 - mdpi.com
… We also examine the potential of stem cell therapy in treating COVID-19 multi-organ failure
… these proinflammatory cytokines, also known as the cytokine storm. Cytokine storms lead to …

… well as their precursor cells and becomes activated in nlrp3 inflammasome-dependent manner by virus spike protein-a potential pathway leading to a “cytokine storm

M Kucia, K Bujko, A Ciechanowicz, M Cymer… - Blood, 2020 - Elsevier
… We hypothesized that one of the triggers of a cytokine storm could be … cells including
population of stem cells. Materials and Methods. Experiments were performed on human stem cells

Insights into the use of mesenchymal stem cells in COVID-19 mediated acute respiratory failure

N Durand, J Mallea, AC Zubair - NPJ Regenerative medicine, 2020 - nature.com
… Widespread inflammation, cytokine storm syndrome and a dysregulated immune response
mediates the severe clinical manifestations seen in high-risk individuals with COVID-19 15,16…

Cytokine storm in COVID-19: the current evidence and treatment strategies

Y Tang, J Liu, D Zhang, Z Xu, J Ji, C Wen - Frontiers in immunology, 2020 - frontiersin.org
… identify the cytokine storm. In this review, we referred COVID-19 associated cytokine storm as
… patients who are severely ill along with a high concentration of pro-inflammatory cytokines. …

[HTML][HTML] Can stem cells beat COVID-19: advancing stem cells and extracellular vesicles toward mainstream medicine for lung injuries associated with SARS-CoV-2 …

W Chrzanowski, SY Kim, L McClements - Frontiers in Bioengineering …, 2020 - frontiersin.org
… In this review article, we outline the mechanisms of cytokine storm and lung damage caused
by SARS-CoV-2 virus leading to COVID-19 disease and how mesenchymal stem cells (…

Pharmacotherapeutics for cytokine storm in COVID-19

R Pal, MJ Chaudhary - Stem Cells, 2024 - Elsevier
Cytokine release syndrome is a life-threatening systemic … of immune cells, resulting in elevated
levels of circulating cytokines. … Cytokine storm is believed to have a worse prognosis and …

Pathogenesis and treatment of cytokine storm in COVID-19

M Soy, G Keser, MP Atagündüz - Turkish Journal of Biology, 2021 - journals.tubitak.gov.tr
… Other therapeutic options: Some clinicians proposed to use stem cells or low-dose radiation
… through the regulatory effects on specialized immune cells in severe COVID-19. Several …