… , Lever, that systematically maps metazoan DNA regulatory motifs or motif combinations to sets of genes. Lever assesses whether the motifs are enriched in cis-regulatory modules (…
… This paper offers a systematic approach to analyzing the elements, linkages, and underlying logic of policy designs. The approach integrates and applies multiple concepts from the …
E Tompa, C Kalcevich, M Foley… - American journal of …, 2016 - Wiley Online Library
Background We aimed to determine the strength of evidence on the effectiveness of legislative and regulatory policy levers in creating incentives for organizations to improve …
J Hamm, K Sullivan, AJ Clippinger, J Strickland, S Bell… - Toxicology In Vitro, 2017 - Elsevier
… have been directed at identifying non-animal alternatives for in vivo acute systemic toxicity tests. The multiple mechanisms associated with acute systemic toxicity preclude a single cell- …
… regulatoryprograms governing diverse aspects of RNA biology remain largely uncharacterized. Understanding the functional roles of RNA cis-regulatory elements … regulatoryprograms. …
L Fei, H Chen, L Ma, WE, R Wang, X Fang, Z Zhou… - Nature Genetics, 2022 - nature.com
… regulatoryprograms during cell-type maturation. We also found lineage-common regulatory programs … In particular, we identified Xbp1 as an evolutionarily conserved regulator of cell-…
T Goedecke, DR Morales, A Pacurariu… - British Journal of …, 2018 - Wiley Online Library
… of regulatory interventions is important but there is currently no common methodological approach to guide this evaluation. This systematic … Our systematic review aimed to describe …
S Liu, Y Liu, Q Zhang, J Wu, J Liang, S Yu, GH Wei… - Genome biology, 2017 - Springer
… binding sites, are associated with genomic regulatory activity [8, 26]. To assess the endogenous chromatin features of the identifiedregulatory elements, we analyzed the available …
M Grskovic, C Chaivorapol, A Gaspar-Maia, H Li… - PLoS …, 2007 - journals.plos.org
… This study provides novel insights into the transcriptional regulatory networks of pluripotent cells. Our results suggest that this systematic approach can be broadly applied to …