Development of therapeutic antibodies for the treatment of diseases

RM Lu, YC Hwang, IJ Liu, CC Lee, HZ Tsai… - Journal of biomedical …, 2020 - Springer
… This review summarizes the latest market trends and outlines the preeminent antibody
engineering technologies used in the development of therapeutic antibody drugs, such as …

The determination and interpretation of the therapeutic index in drug development

PY Muller, MN Milton - Nature reviews Drug discovery, 2012 - nature.com
… and interpretation in drug development for both small molecule drugs and biotherapeutics. …
during drug discovery and development for both small-molecule drugs and biotherapeutics. …

[HTML][HTML] Recent advances in (therapeutic protein) drug development

HAD Lagassé, A Alexaki, VL Simhadri… - …, 2017 - ncbi.nlm.nih.gov
… In this review, we highlight the emerging trends and approaches in protein drug
development by using examples of therapeutic proteins approved by the US Food and Drug

[HTML][HTML] Challenges in the development of drugs for the treatment of tuberculosis

A Shehzad, G Rehman, M Ul-Islam, WA Khattak… - The Brazilian journal of …, 2013 - Elsevier
… other drugs for the treatment of TB infections. The use of RIF in combination with PZA/INH
led to the establishment of short therapy courses, which reduced routine TB treatment from 1 …

Advances in the development of new tuberculosis drugs and treatment regimens

A Zumla, P Nahid, ST Cole - Nature reviews Drug discovery, 2013 - nature.com
… weeks of therapy, 6 months of treatment with currently available drugs is required to … therapy
including the following: drug intolerance and toxicities, with the resultant need for treatment

Clinical development times for innovative drugs

DG Brown, HJ Wobst, A Kapoor, LA Kenna… - Nat Rev Drug …, 2022 - nature.com
… The two drugs with the shortest clinical development time … cancer treatment) and elexacaftor
(a cystic fibrosis treatment). … and the triple combination therapy including this drug, Trikafta, …

The prospects for “personalized medicine” in drug development and drug therapy

J Woodcock - Clinical Pharmacology & Therapeutics, 2007 - Wiley Online Library
… currently problematic states of both drug development and therapy. … drug therapies and the
promulgation of evidence-based best practices. Development of evidence-based therapeutic

Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies

S Tiberi, N du Plessis, G Walzl, MJ Vjecha… - The Lancet Infectious …, 2018 - thelancet.com
… as adjunctive therapy for shortening duration of therapy, preventing permanent lung injury,
and improving treatment outcomes of MDR tuberculosis. We discuss the HDT development

[PDF][PDF] Anti-angiogenic therapeutic drugs for treatment of human cancer

HC Wu, CT Huang, DK Chang - J Cancer Mol, 2008 - researchgate.net
… towards the development of drugs that disrupt or normalize this process for cancer therapy.
Some … In this review article, we summarize the clinical use of small molecules and therapeutic

New antituberculous drugs in development

UG Lalloo, A Ambaram - Current HIV/AIDS Reports, 2010 - Springer
… that are safe, effective against resistant strains, are able to shorten the course of treatment, …
with antiretroviral drugs. Drugs that are currently in phase 3 development are moxifloxacin …