Cytokines: principles and prospects

A Kelso - Immunology and cell biology, 1998 - Wiley Online Library
… of the cytokine network has hindered the widespread clinical application of many cytokines
… and disease is needed for the therapeutic potential of cytokines to be fully realized. This …

PPAR-γ: therapeutic prospects in Parkinson's disease

AR Carta - Current drug targets, 2013 - ingentaconnect.com
… Supporting a dysregulated peripheral immune response in PD, high levels of serum
interleukins and pro-inflammatory cytokines have been described in PD patients [21, 43-45]. …

Inflammatory cytokines in atherosclerosis: current therapeutic approaches

D Tousoulis, E Oikonomou, EK Economou… - European heart …, 2016 - academic.oup.com
The notion of atherosclerosis as a chronic inflammatory disease has intensified research on
the role of cytokines and the way these molecules act and interact to initiate and sustain …

Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

K Rajasekhar, T Govindaraju - RSC advances, 2018 - pubs.rsc.org
pro-inflammatory cytokines. In microglia, p38 MAPK activate the release of tumor necrosis
factor-alpha (TNF-α) and IL-1β (pro-inflammatory cytokines… of pro-inflammatory cytokines such …

Recent progress and prospects for anti-cytokine therapy in preclinical and clinical acute lung injury

GP Fadanni, JB Calixto - Cytokine & Growth Factor Reviews, 2023 - Elsevier
… In this review, we provide an overview of anti-cytokine therapy for acute lung injury and …
targeting the main cytokines individually and the therapeutic prospects for combination therapy. …

Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

M Li, Y Jiang, Q Hou, Y Zhao, L Zhong, X Fu - … cell research & therapy, 2022 - Springer
therapy have spanned across various diseases in experimental and clinical researches
worldwide, exhibiting therapeutic … ideal seed cells in cell therapy after haematopoietic stem cells. …

Inflammatory cytokines in cancer: comprehensive understanding and clinical progress in gene therapy

T Lan, L Chen, X Wei - Cells, 2021 - mdpi.com
… using gene therapies. Hence, it is important to comprehensively analyze clinical progress
in such gene therapies to evaluate their therapeutic prospects. The concept of gene therapy is …

[PDF][PDF] Pro-inflammatory cytokines as potential early biomarkers and therapeutic targets to combat ischemic stroke

M Agrawal - 2023 - academia.edu
… This creates bright prospects for new stroke therapies. However, it is also speculated that
such immunomodulation could produce some side effects as well. Therefore, it is thought that a …

Historical review: cytokines as therapeutics and targets of therapeutics

J Vilček, M Feldmann - Trends in pharmacological sciences, 2004 - cell.com
cytokine therapeutics include hematopoietic growth factors (colony stimulating factors) and
interferons. Prime examples of cytokine … introduction of cytokine and anti-cytokine therapies, …

Oxygen-sensitive pro-inflammatory cytokines, apoptosis signaling and redox-responsive transcription factors in development and pathophysiology

JJ Haddad - Cytokines, cellular & molecular therapy, 2002 - Taylor & Francis
… and pro-inflammatory cytokines. This review concerns redox signaling and gene regulation,
and the role of oxygenation in determining cell fate and the downstream inflammatory state. …