Towards a pro-inflammatory and immunomodulatory emerging role of leptin

M Otero, R Lago, R Gomez, C Dieguez, F Lago… - …, 2006 - academic.oup.com
… and prospects for the future. … a new pro-inflammatory cytokine with direct actions on
immune-inflammatory response. This adipokine could be considered as a new potential therapeutic

IL-4 adenoviral gene therapy reduces inflammation, proinflammatory cytokines, vascularization, and bony destruction in rat adjuvant-induced arthritis

JM Woods, KJ Katschke, MV Volin, JH Ruth… - The Journal of …, 2001 - journals.aai.org
… In the present study there were some differences between the effects of IL-4 on proinflammatory
cytokines in ankles when administered before and after disease onset. Preventative …

Autoantibodies to TNFα in HIV-1 infection: prospects for anti-cytokine vaccine therapy

CJ Capini, MW Richardson, H Hendel… - Biomedicine & …, 2001 - Elsevier
… ) is a proinflammatory cytokine principally involved in the activation of lymphocytes in
response to viral infection. TNFα also stimulates the production of other cytokines, activates NK …

Therapeutic opportunities in systemic lupus erythematosus: state of the art and prospects for the new decade

GK Bertsias, JE Salmon, DT Boumpas - Annals of the rheumatic …, 2010 - ard.bmj.com
… Homocysteine and proinflammatory cytokines impair endothelial function and decrease
the availability of endothelial precursor cells to repair endothelial injury. Production of …

Prospects and challenges of using chicken cytokines in disease prevention

MM Rahman, SK Eo - Vaccine, 2012 - Elsevier
… Before reviewing recent updates regarding chicken cytokines and their therapeutic
applications, we feel it is appropriate to begin by providing a short description of the immune …

Selective JAKinibs: prospects in inflammatory and autoimmune diseases

AT Virtanen, T Haikarainen, J Raivola, O Silvennoinen - BioDrugs, 2019 - Springer
… Each cytokine receptor recruits and employs a specific combination of JAK kinases, which
has important implications in therapeutic targeting of JAKs in various disease entities (Fig. 2) [4…

JAK–STAT signaling as a target for inflammatory and autoimmune diseases: current and future prospects

S Banerjee, A Biehl, M Gadina, S Hasni, DM Schwartz - Drugs, 2017 - Springer
… Given the involvement of STATs in signaling events downstream of cytokine receptors as
well as growth factors, STATs have long been considered as potential therapeutic targets for …

Research status and application prospect of cytokine therapy for osteoarthritis

K Zhang, H Shi - Chinese Journal of Tissue Engineering Research, 2024 - cjter.com
… associated with cytokines and signaling … cytokines and signaling pathways as
therapeutic breakthroughs are also the current hot spot. (2) The receptor antagonists of pro-inflammatory

The cytokines of bovine mammary gland: prospects for diagnosis and therapy

AM Alluwaimi - Research in veterinary science, 2004 - Elsevier
… is to evaluate cytokines as therapeutic, prognostic and … the pro-inflammatory cytokines in
driving the pathogenicity and outcome of the infection has biased the investigation of cytokine's

Bacterial proteases: current therapeutic use and future prospects for the development of new antibiotics

CT Supuran, A Scozzafava… - … Opinion on Therapeutic …, 2001 - Taylor & Francis
… Bacteria seem to possess all the major types of serine PRs mentioned in Table 1 and those
with potential therapeutic applications will be discussed in this chapter. Bacterial SPRs not …