The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies

N Zhao, B Di, L Xu - Cytokine & growth factor reviews, 2021 - Elsevier
NLRP3 inflammasome activation pathway. Second, we review the cellular/molecular
mechanisms of NLRP3 inflammasome … the involvement of the NLRP3 inflammasome in the …

[HTML][HTML] Targeting the NLRP3 inflammasome as a new therapeutic option for overcoming cancer

S Missiroli, M Perrone, C Boncompagni, C Borghi… - Cancers, 2021 - mdpi.com
… In this review, we will discuss the NLRP3 inflammasome as a … on current strategies for targeting
the NLRP3 inflammasome, … and that targeting NLRP3 is a promising therapeutic strategy. …

Targeting the NLRP3 inflammasome in inflammatory diseases

MSJ Mangan, EJ Olhava, WR Roush… - Nature reviews Drug …, 2018 - nature.com
… Pharmacological inhibition of NLRP3 activation results in potent therapeutic effects in a
wide variety of rodent models of inflammatory diseases, effects that are mirrored by genetic …

[HTML][HTML] Phytochemicals as novel therapeutic strategies for NLRP3 inflammasome-related neurological, metabolic, and inflammatory diseases

C Pellegrini, M Fornai, L Antonioli, C Blandizzi… - International journal of …, 2019 - mdpi.com
… about the pathophysiological role of NLRP3 inflammasome pathways in such … NLRP3
inflammasome by phytochemicals could represent a promising molecular target for the therapeutic

[HTML][HTML] Chronic kidney disease and NLRP3 inflammasome: Pathogenesis, development and targeted therapeutic strategies

G Huang, Y Zhang, Y Zhang, Y Ma - Biochemistry and biophysics reports, 2023 - Elsevier
… of CKD, but the mechanism behind inflammasome activation in CKD remains obscure.In this
… the NLRP3 inflammasome in CKD and new strategies targeting the NLRP3 inflammasome. …

The NLRP3 inflammasome: Mechanism of action, role in disease and therapies

L Wang, AV Hauenstein - Molecular aspects of medicine, 2020 - Elsevier
… mechanisms of NLRP3 inflammasome activation, how dysregulation of NLRP3 inflammasome
activation causes disease, and potential therapeutics that inhibit NLRP3 inflammasome

Strategies for targeting the NLRP3 inflammasome in the clinical and preclinical space

AG Schwaid, KB Spencer - Journal of Medicinal Chemistry, 2020 - ACS Publications
… the excitement in the field for NLRP3 as a therapeutic target. As compounds progress, …
strategies have not been published, particularly considering the similar mode of action on NLRP3

The strategies of targeting the NLRP3 inflammasome to treat inflammatory diseases

H Jiang, T Gong, R Zhou - Advances in immunology, 2020 - Elsevier
strategies of targeting the NLRP3 inflammasome and their clinical potential to treat NLRP3-…
-tolerated drug, the clinical therapeutic effect of tranilast on NLRP3-related diseases needs …

The involvement of NLRP3 inflammasome in the treatment of Alzheimer's disease

YS Feng, ZX Tan, LY Wu, F Dong, F Zhang - Ageing research reviews, 2020 - Elsevier
… of the molecular mechanisms associated with the onset and progression of AD is critical to
provide a theoretical basis for the establishment of novel preventive and therapeutic strategies

Molecular mechanisms regulating NLRP3 inflammasome activation

EK Jo, JK Kim, DM Shin, C Sasakawa - Cellular & molecular …, 2016 - nature.com
… Our knowledge of the mechanisms regulating NLRP3 inflammasometherapeutic strategies
to treat inflammatory diseases associated with dysregulation of the NLRP3 inflammasome. …