A “window of therapeutic opportunity” for anti-cytokine therapy in patients with coronavirus disease 2019

L De Stefano, F Bobbio-Pallavicini, A Manzo… - Frontiers in …, 2020 - frontiersin.org
… The relative contribution of viral damage and of innate and adaptive immune responses
in course of COVID-19 greatly varies over time (31–33). In the early phases, common to all …

Potential therapeutic options for COVID-19: current status, challenges, and future perspectives

C Sarkar, M Mondal, M Torequl Islam… - Frontiers in …, 2020 - frontiersin.org
… A very recent study showed that this antiviral, originally developed against Ebola hemorrhagic
fever, slightly reduces the recovery time of patients hospitalized with Covid-19 (15 to 11 …

[HTML][HTML] Challenges at the Time of COVID-19: Opportunities and Innovations in Antivirals from Nature

A Hensel, R Bauer, M Heinrich, V Spiegler… - Planta …, 2020 - thieme-connect.com
… As viral infections are an increasing threat to human societies, the need for new therapeutic
strategies is becoming even more obvious. As no vaccine is available for COVID-19, the …

Storm at the time of corona: a glimpse at the current understanding and therapeutic opportunities of the SARS-CoV-2 cytokine storm

M Torabi-Rahvar, N Rezaei - Current Pharmaceutical Design, 2021 - ingentaconnect.com
… A clinical trial is ongoing at the present time to test an antiC5 antibody … COVID-19, at the
present time. Nevertheless, the idea of using TNF blockers to treat patients with severe COVID-…

[HTML][HTML] Corona (COVID-19) time musings: our involvement in COVID-19 pathogenesis, diagnosis, treatment and vaccine planning

Y Shoenfeld - Autoimmunity reviews, 2020 - ncbi.nlm.nih.gov
… The 2020 coronavirus epidemic is characterized by high infectious rates and relatively high
… to the COVID-19 infection [1,2]. In most of those severe cases of coronavirus infection, the …

COVID-19 therapeutics: Challenges and directions for the future

PC Robinson, DFL Liew, HL Tanner… - Proceedings of the …, 2022 - National Acad Sciences
COVID-19 drug development and highlight important unmet needs. We examine key therapeutic
… Regrettably, the important timing of therapy administration within relevant windows of …

[HTML][HTML] COVID-19 challenges and its therapeutics

SU Rehman, SU Rehman, HH Yoo - Biomedicine & Pharmacotherapy, 2021 - Elsevier
coronavirus that causes COVID-19, has brought together scientists in the quest for possible
therapeutic … new drugs to manage COVID-19 effectively is a challenging and time-consuming …

Potential therapeutic options for COVID-19: an update on current evidence

Z Niknam, A Jafari, A Golchin, F Danesh Pouya… - European journal of …, 2022 - Springer
… Drug repurposing is the best approach to recognize therapeutic options for COVID‑19 in
a limited time [14, 15]. The great benefit of this approach is the available science about the …

Accelerating COVID-19 therapeutic interventions and vaccines (ACTIV): an unprecedented partnership for unprecedented times

FS Collins, P Stoffels - Jama, 2020 - jamanetwork.com
… The Therapeutics Clinical Working Group … therapeutic candidates for COVID-19 with near-term
potential. The goals have been to prioritize and test potential therapeutic agents for COVID

[HTML][HTML] Therapeutic options for COVID-19: a review

R Pujari, MV Thommana, BR Mercedes, A Serwat - Cureus, 2020 - ncbi.nlm.nih.gov
… of coronavirus disease 2019 (COVID-19) has been challenging to define with the emergence
of new symptoms with time. The most common clinical manifestations of COVID-19 include …