Role of matrix metalloproteinases in the pathogenesis of idiopathic pulmonary fibrosis

A Pardo, S Cabrera, M Maldonado, M Selman - Respiratory research, 2016 - Springer
… the mechanisms of wound healing and tissue fibrosis [43]. The … participate in the process of
tissue migration and homing since … the transendothelial and tissue migration of fibrocytes and …

Pathogenic mechanisms underlying idiopathic pulmonary fibrosis

BJ Moss, SW Ryter, IO Rosas - Annual Review of Pathology …, 2022 - annualreviews.org
… ILAs are correlated with histologic evidence of pulmonary fibrosis (4) and with demographic
… proteome analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF), non-…

Airway remodelling and its relationship to inflammation in cystic fibrosis

N Regamey, PK Jeffery, EWFW Alton, A Bush… - Thorax, 2011 - thorax.bmj.com
remodelling which, in this context, has been defined as an alteration in size, mass or number
of tissue … Airway remodelling may already be present in children with CF and, in more than …

[HTML][HTML] Cytokine mediated tissue fibrosis

LA Borthwick, TA Wynn, AJ Fisher - … acta (BBA)-molecular basis of disease, 2013 - Elsevier
… There is significant literature indicating that fibrocytes are associated with organ fibrosis
in pulmonary fibrosis, bronchial asthma, skin wounds, intimal hyperplasia and kidney …

Herpes virus infection is associated with vascular remodeling and pulmonary hypertension in idiopathic pulmonary fibrosis

F Calabrese, A Kipar, F Lunardi, E Balestro… - PLoS …, 2013 - journals.plos.org
… similar to EBV, contributes to the development of vessel remodelling other than pulmonary
fibrosis. … Injured epithelial or endothelial cells involved in tissue and vessel remodelling are …

Structural and functional correlations in a large animal model of bleomycin-induced pulmonary fibrosis

L Organ, B Bacci, E Koumoundouros, G Barcham… - BMC pulmonary …, 2015 - Springer
pulmonary fibrosis is a progressive and fatal disease due to the resulting functional impairment
and respiratory failure caused by aberrant extracellular matrix remodelling … to lung tissue

FTY720 promotes pulmonary fibrosis when administered during the remodelling phase following a bleomycin-induced lung injury

DR Gendron, AM Lemay, PB Lecours… - Pulmonary …, 2017 - Elsevier
… into the airway tissues during the remodelling phase of the … of fibrosis by FTY720 during
the remodelling phase does not … likely results from the promotion of pro-fibrotic mechanisms. …

Meprin β, a novel mediator of vascular remodelling underlying pulmonary hypertension

V Biasin, LM Marsh, B Egemnazarov… - The Journal of …, 2014 - Wiley Online Library
… Very similar remodelling is found in patients with interstitial … tissue disease, in whom even
mild elevations of pulmonary arterial … remodelling, which leads to the obliteration of pulmonary

Pulmonary fibrosis from molecular mechanisms to therapeutic interventions: lessons from post-COVID-19 patients

C Giacomelli, R Piccarducci, L Marchetti… - Biochemical …, 2021 - Elsevier
Pulmonary fibrosis (PF) is characterised by several grades of chronic … tissue diseases (eg
rheumatoid arthritis and systemic sclerosis) but also other less-characterized connective tissue

Fibrosis: from mechanisms to medicines

NC Henderson, F Rieder, TA Wynn - Nature, 2020 - nature.com
… The genes involved include MUC5B in pulmonary fibrosis 2 , MYH7 in cardiac fibrosis 3 , …
cavity macrophages are also key contributors to fibrosis and tissue remodelling. For example, a …