von Willebrand factor disruption and continuous-flow circulatory devices
AG Proudfoot, SJ Davidson, M Strueber - The Journal of Heart and Lung …, 2017 - Elsevier
Bleeding events remain a significant and frequent complication of continuous-flow left
ventricular assist devices (VADs). von Willebrand factor (VWF) is critical to hemostasis by
acting as a bridging molecule at sites of vascular injury for normal platelet adhesion as well
as promoting platelet aggregation under conditions of high shear. Clinical and experimental
data support a role for acquired von Willebrand disease in VAD bleeding episodes caused
by shear-induced qualitative defects in VWF. Pathologic shear induces VWF unfolding and …
ventricular assist devices (VADs). von Willebrand factor (VWF) is critical to hemostasis by
acting as a bridging molecule at sites of vascular injury for normal platelet adhesion as well
as promoting platelet aggregation under conditions of high shear. Clinical and experimental
data support a role for acquired von Willebrand disease in VAD bleeding episodes caused
by shear-induced qualitative defects in VWF. Pathologic shear induces VWF unfolding and …
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