Urokinase-type plasminogen activator has been administered by other investigators to
patients with small cell carcinoma of the lung (SCCL) in an attempt to induce lysis of fibrin …

Twenty-five patients were treated with intensive chemotherapy for small cell carcinoma of
the lung. Twelve patients received concurrent urokinase and combination chemotherapy in …

Components of coagulation and fibrinolysis reactions were identified in situ by
immunohistochemical staining in fresh frozen sections of small cell carcinoma of the lung …

The plasminogen activator content of surgically removed lung cancers, as well as that of
adjacent normal lung tissue has been determined quantitatively. Optimum conditions for the …

The HPL-SK-1 cell line derived from the pleural exudate of a lung cancer patient has been
shown to secrete plasminogen activators of very high molecular weights (greater than or …

The invasively growing and metastasizing Lewis lung carcinoma consistently contained
urokinase-type plasminogen activator (u-PA) enzyme activity. When investigated …

Local and systemic changes in the hemostatic system are related to the process of local
tumor growth and metastasis. The association of these complications with laboratory …

Several tumor cells secrete significantly increased amounts of the plasminogen activator
urokinase, a trypsinlike serine protease, whose biological function in tumor biology is …

A new screening test is described which enabled rapid determination of the proportion of
single-chain and two-chain urokinase produced in the culture supernatants of 18 human cell …

In this paper we summarize experiments in which murine melanoma B16-F1 cells of low
metastatic potential were transfected with the human gene for prep rourokinase. B16-F1 …