Bombesin/GRP and vasoactive intestinal peptide/PACAP as growth factors
Publisher Summary Bombesin (BB) was the first peptide identified as a cancer cell autocrine
growth factor. High levels of immunoreactive BB were detected in small-cell lung cancer …
growth factor. High levels of immunoreactive BB were detected in small-cell lung cancer …
GRP-receptor-mediated signal transduction, gene expression and DNA synthesis in the human pancreatic adenocarcinoma cell line HPAF
B Burghardt, C Wenger, K Barabás, G Rácz, A Oláh… - Peptides, 2001 - Elsevier
Bombesin-like peptides have been implicated as growth factors in various human cancers.
Human adenocarcinoma cell lines (Capan-1, Capan-2, MiaPaCa-2 and HPAF) were tested …
Human adenocarcinoma cell lines (Capan-1, Capan-2, MiaPaCa-2 and HPAF) were tested …
The release of bombesin-like peptides from small cell lung cancer cells.
TW Moody, LY Korman - Annals of the New York Academy of …, 1988 - europepmc.org
High levels of BN/GRP are present in classic SCLC and lung carcinoids, whereas BN
immunoreactivity is absent in variant SCLC, adenocarcinoma, large cell carcinoma …
immunoreactivity is absent in variant SCLC, adenocarcinoma, large cell carcinoma …
Gut hormones with activity to modulate cellular growth
K Yamaguchi - Human Cell, 1990 - europepmc.org
Recent progress in cancer research revealed that gut hormones have the activity to regulate
the cellular growth of cancer cells. Gastrin, cholecystokinin and vasoactive intestinal peptide …
the cellular growth of cancer cells. Gastrin, cholecystokinin and vasoactive intestinal peptide …
Bombesin-like peptides as growth factors.
CJ Wiedermann - Wiener Klinische Wochenschrift, 1989 - europepmc.org
Bombesin-like peptides (BN-LP) are involved in the regulation of many important functions,
including sensory transmission, regulation of central autonomic pathways, thermoregulation …
including sensory transmission, regulation of central autonomic pathways, thermoregulation …
The proliferative response of HT-29 human colon adenocarcinoma cells to bombesin-like peptides
G Cassano, N Resta, G Gasparre, C Lippe, G Guanti - Cancer letters, 2001 - Elsevier
Bombesin-like peptides (BLP) and their receptors are widely distributed throughout the
intestine and are potential mitogens for gastrointestinal cancers. In this study we …
intestine and are potential mitogens for gastrointestinal cancers. In this study we …
VIP as a trophic factor in the CNS and cancer cells
The effects of vasoactive intestinal peptide (VIP) on the proliferation of central nervous
system (CNS) and cancer cells were investigated. VIP has important actions during CNS …
system (CNS) and cancer cells were investigated. VIP has important actions during CNS …
Gastrin-releasing peptide (GRP, mammalian bombesin) in the pathogenesis of lung cancer
J Viallet, JD Minna - Progress in Growth Factor Research, 1989 - Elsevier
Established human lung cancer exhibits a complex pattern of genetic changes as well as
several distinct autocrine growth factor loops for regulatory peptides. The best studied …
several distinct autocrine growth factor loops for regulatory peptides. The best studied …
Bombesin stimulates proliferation of human breast cancer cells in culture.
The discovery of the amphibian skin tetradecapeptide bombesin led to the identification of
several mammalian bombesin-like neuroendocrine peptides such as gastrinreleasing …
several mammalian bombesin-like neuroendocrine peptides such as gastrinreleasing …
Neuropeptides as autocrine growth factors in cancer cells
TW Moody, D Chan, J Fahrenkrug… - Current …, 2003 - ingentaconnect.com
Neuropeptides can function as autocrine growth factors in cancer cells. High levels of
bombesin (BB) and neurotensin (NT)-like immunoreactivity are present in small cell lung …
bombesin (BB) and neurotensin (NT)-like immunoreactivity are present in small cell lung …