Variabilin, a novel RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis

X Wang, LB Coons, DB Taylor, SE Stevens… - Journal of Biological …, 1996 - ASBMB
A novel inhibitor of human platelet aggregation, named variabilin, was isolated from salivary
glands of the hard tick Dermacentor variabilis using a combination of gel filtration and high …

Savignygrin, a platelet aggregation inhibitor from the soft tickOrnithodoros savignyi, presents the RGD integrin recognition motif on the Kunitz-BPTI fold

BJ Mans, AI Louw, AWH Neitz - Journal of Biological Chemistry, 2002 - ASBMB
Savignygrin, a platelet aggregation inhibitor that possesses the RGD integrin recognition
motif, has been purified from the soft tick Ornithodoros savignyi. Two isoforms with similar …

[HTML][HTML] Decorsin. A potent glycoprotein IIb-IIIa antagonist and platelet aggregation inhibitor from the leech Macrobdella decora.

JL Seymour, WJ Henzel, B Nevins, JT Stults… - Journal of Biological …, 1990 - Elsevier
The discovery, purification, and characterization of decorsin, a protein isolated from the
North American leech Macrobdella decora, are described. Decorsin acts as an antagonist of …

Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: evidence for a family of platelet-aggregation inhibitors.

MS Dennis, WJ Henzel, RM Pitti… - Proceedings of the …, 1990 - National Acad Sciences
The purification, complete amino acid sequence, and biological activity are described for
several homologous snake venom proteins that are platelet glycoprotein (GP) IIb-IIIa …

Identification of the disulfide bond pattern in albolabrin, an RGD-containing peptide from the venon of trimeresurus albolabris: Significance for the express of platelet …

JJ Calvete, W Schaefer, T Soszka, W Lu, J Cook… - Biochemistry, 1991 - ACS Publications
Revised Manuscript Received February 14, 1991 abstract: Albolabrin is a 73 amino acid
peptide isolated from the venom of Trimeresurus albolabris. It contains an RGD sequence …

Mambin, a potent glycoprotein IIb-IIIa antagonist and platelet aggregation inhibitor structurally related to the short neurotoxins

RS McDowell, MS Dennis, A Louie, M Shuster… - Biochemistry, 1992 - ACS Publications
Revised Manuscript Received February 6, 1992 abstract: The purification, complete amino
acid sequence, functional activity, and structural modeling are described for mambin, a …

Chrysoptin is a potent glycoprotein IIb/IIIa fibrinogen receptor antagonist present in salivary gland extracts of the deerfly

VB Reddy, K Kounga, F Mariano, EA Lerner - Journal of Biological …, 2000 - ASBMB
Salivary gland lysates of the deerfly (genusChrysops) contain chrysoptin, an inhibitor of ADP-
induced platelet aggregation, which presumably assists the fly in obtaining a blood meal …

Purification and molecular cloning of a platelet aggregation inhibitor from the snake (Agkistrodon halys brevicaudus) venom

IC Kang, KH Chung, SJ Lee, Y Yun, HM Moon… - Thrombosis research, 1998 - Elsevier
A platelet glycoprotein IIb-IIIa (GP IIb-IIIa) antagonist, salmosin, was purified to homogeneity
from Korean snake (Agkistrodon halys brevicaudus) venom by means of chromatographic …

A novel family of RGD-containing disintegrins (Tablysin-15) from the salivary gland of the horsefly Tabanus yao targets αIIbβ3 or αVβ3 and inhibits platelet …

D Ma, X Xu, S An, H Liu, X Yang… - Thrombosis and …, 2011 - thieme-connect.com
A novel family of RGD-containing molecules (Tablysin-15) has been molecularly
characterised from the salivary gland of the haematophagous horsefly Tabanus yao …

Ornatins: potent glycoprotein IIb‐IIIa antagonists and platelet aggregation inhibitors from the leech Placobdella ornata

P Mazur, WJ Henzel, JL Seymour… - European journal of …, 1991 - Wiley Online Library
The purification and characterization of six isoforms of ornatin, potent glycoprotein IIb‐IIIa
(GP IIb‐IIIa) antagonists and platelet aggregation inhibitors are described. These isoforms …