Rapid and yet precisely controlled changes in cell adhesion are a hallmark of a number of
basic physiological processes. Many of these processes directly impact upon nephrology …

Emerging paradigms of integrin ligand binding and activation. Adhesion of cells to each
other or to the extracellular matrix provides essential signals that regulate many cellular …

Integrins are heterodimeric cell surface receptors that mediate heterophilic cell-cell
interactions and interactions between cells and the extracellular matrix (Hynes RO. Cell 69 …

The term ‚integrin'was proposed by Richard Hynes to describe a family of integral
membrane receptors thought to link or “integrate” the cytoskeleton of one cell with that of …

A major function of the integrin family of receptors is to provide a physical connection
between extracellular adhesion proteins and intracellular cytoskeletal/signalling molecules …

Previous articles in this series have emphasized the fundamental importance of adhesion
receptors in vascular biology. One class of these receptors, the integrins, is necessary for …

Integrin cell-adhesion receptors mediate interactions between cells and the extracellular
matrix. Dynamic regulation of integrin adhesive function is termedactivation'orinside …

Integrin signaling is bidirectional.'Inside-out'signals regulate integrin affinity for adhesive
ligands, and ligand-dependent 'outside-in'signals regulate cellular responses to adhesion …

Integrins represent a superfamily of cell surface molecules that are important mediators of
cell-extracellular matrix interactions. Of the many known integrin subunit combinations, only …

Integrin receptors and function on cultured glomerular endothelial cells. Integrin expression
and function on a cloned line of rat glomerular endothelial cells (GEndoC) were studied in …