We characterized a murine monoclonal antibody, PT25-2 (IgG 1), raised against washed
human platelets. The antibody and its Fab fragments were both capable of inducing platelet …

Peptides derived from a sequence within the loop structure of human platelet glycoprotein
(GP) IIIa (integrin beta 3) were previously shown to inhibit fibrinogen binding to purified …

The integrin [alpha] IIb [beta] 3 (GPIIb/IIIa) mediates platelet aggregation by a change in
affinity for the ligand fibrinogen. The amino acids 991-995 (GFFKR) at the NH2-terminus of …

We have developed two monoclonal antibodies (MAbs), B6A3 and C4G1. The whole
molecules of the two MAbs inhibited in vitro human platelet aggregation induced by either …

Fibrinogen binding to the integrin αIIbβ3 mediates platelet aggregation and spreading on
fibrinogen-coated surfaces. However, in vivo αIIbβ3 activation and fibrinogen conversion to …

The monoclonal antibodies Tab and AP3 are directed, respectively, against GPIIb and
GPIIIa, the subunits of the platelet fibrinogen receptor. When added together to platelets …

Abstract The IIb-IIIa glycoprotein complex is a favored target for allo-, auto-, and drug-
dependent antibodies associated with immune thrombocytopenia. A soluble, recombinant …

Platelet glycoproteins αIIb and β3 are membrane proteins that associate to form a Ca2+‐
dependent heterodimer which constitutes an inducible member of the integrin family at the …

The human integrin glycoprotein IIb/IIIa complex plays a central role in haemostasis as an
inducible receptor for fibrinogen and other adhesive proteins at the platelet plasma …

Platelet integrin receptor αIIbβ3 supports platelet aggregation by binding fibrinogen. The
interaction between the fibrinogen C-terminal γ-chain peptide composed of residues γ-404 …