Distinct themes exist for ligand-binding domains of G protein-coupled receptors. The
secretin receptor is prototypic of a recently described family in this superfamily which binds …

An understanding of the molecular basis of hormonal activation of receptors provides
important insights for drug design. Toward this end, intrinsic photoaffinity labeling is a …

Photoaffinity labeling is a powerful tool for the characterization of the molecular basis of
ligand binding. We recently used this technique to demonstrate the proximity between a …

The secretin receptor is prototypic of the class II family of G protein-coupled receptors, with a
long extracellular amino-terminal domain containing six highly conserved Cys residues and …

The contribution of the extracellular loops of the secretin receptor to the recognition of
secretin was investigated by transfection in CHO cells of chimeric receptors, in which the …

The secretin receptor was the first member of the Class II family of G protein-coupled
receptors to be cloned. It is prototypic of this family in its structure, function, and regulation …

The carboxyl-terminal domains of secretin family peptides have been shown to contain key
determinants for high affinity binding to their receptors. In this work, we have examined the …

The secretin receptor is prototypic of Class II GPCRs (G-protein-coupled receptors), based
on its structural and functional characteristics and those of its natural agonist ligand. Secretin …

The secretin receptor belongs to a recently recognized family of G protein-coupled receptors
that lack the sequence motifs typical of the beta-adrenergic receptor family. Because our …

The class B family of G protein-coupled receptors contains several potentially important drug
targets, yet our understanding of the molecular basis of ligand binding and receptor …