Bisphosphonates (once called diphosphonates) are analogues of pyrophosphates.
Pyrophosphates are ubiquitous compounds that are rapidly degraded in vivo by …

Bisphosphonates are potent antiresorptive agents useful for the prevention and treatment of
osteoporosis and other conditions characterized by increased bone remodeling. Chemically …

Bisphosphonates are avid bone-seeking compounds with potent antiresorptive effects. The
share a common chemical structure (Fig. 1) of two phosphonic acids joined to a carbon, with …

T he bisphosphonates, formerly diphosphonates, are a class of synthetic analogues of
pyrophosphate, with a phosphate-calcium-phosphate(PCP) instead of a phosphate-oxygen …

Bisphosphonates are non-biodegradable compounds characterized by a phosphorus-
carbon-phosphorus bond. By substituting the hydrogens on the carbon atom, a variety of …

Bisphosphonates: Safety and Efficacy in the Treatment and Prevention of Osteoporosis | AAFP
Advertisement search close brand logo SUSAN L. GREENSPAN, MD, STEVEN T. HARRIS …

Bisphosphonates are synthetic compounds that are taken up preferentially by the skeleton
and suppress osteoclast-mediated bone resorption. There are structural differences among …

Bisphosphonates are compounds derived from pyrophosphate, a byproduct of cellular
cleavage of adenosine triphosphate (ATP), and are resistant to alkaline phosphatase by …

The bisphosphonates are synthetic compounds characterized by a PCP bond. They have a
strong affinity to calcium phosphates and hence to bone mineral. In vitro they inhibit both …

Bisphosphonates are a class of drugs that have been developed in the past 2 decades for
use in various diseases of bone metabolism. The development of these drugs has been …