In vivo treatment of rats with unfractionated heparin (UFH) or low molecular weight heparin (LMWH) does not affect experimentally induced colon carcinoma …

SM Smorenburg, R Vink, M te Lintelo… - Clinical & experimental …, 1999 - Springer
Recent randomized trials have suggested that treatment with low molecular weight heparin
(LMWH) improves survival of cancer patients with venous thromboembolism, as compared …

Do heparins do more than just treat thrombosis? The influence of heparins on cancer spread

RJK Hettiarachchi, SM Smorenburg… - Thrombosis and …, 1999 - thieme-connect.com
The influence of unfractionated heparin (UFH) and other anticoagulants on the spread of
cancer has been reported since the early 1960s. 1 However, clinical studies investigating …

The effects of low molecular weight heparins on venous thromboembolism and survival in patients with cancer

AYY Lee - Thrombosis Research, 2007 - Elsevier
Monotherapy with low molecular weight heparin (LMWH) is superior to vitamin K antagonists
in preventing recurrent venous thromboembolism (VTE) in patients with cancer and may …

The complex effects of heparins on cancer progression and metastasis in experimental studies

SM Smorenburg, CJF Van Noorden - Pharmacological reviews, 2001 - ASPET
Patients with cancer are frequently treated with anticoagulants, including heparins, to treat or
to prevent thrombosis. Recent randomized trials that compared low molecular weight …

The heparins and cancer: review of clinical trials and biological properties

R Castelli, F Porro, P Tarsia - Vascular medicine, 2004 - journals.sagepub.com
The association between cancer and thromboembolic disease is a well-known phenomenon
and can contribute significantly to the morbidity and mortality of cancer patients. The …

Treatment with modified heparins inhibits experimental metastasis formation and leads, in some animals, to long-term survival.

T Sciumbata, P Caretto, P Pirovano, P Pozzi… - Invasion & …, 1996 - europepmc.org
Two chemically modified heparins with low anticoagulant activity were studied in terms of
their antimetastatic activity in the B16-BL6 melanoma model. The two heparins were a very …

Unfractionated and Low Molecular Weight Heparin Affect Fibrin Structure and Angiogenesis in Vitro

A Collen, SM Smorenburg, E Peters, F Lupu… - Cancer research, 2000 - AACR
Cancer patients treated for venous thromboembolism with low molecular weight heparin
(LMWH) have a better survival rate than patients treated with unfractionated heparin (UFH) …

[HTML][HTML] Endothelial barrier protective properties of low molecular weight heparin: A novel potential tool in the prevention of cancer metastasis?

B Kevane, K Egan, S Allen, P Maguire, E Neary… - Research And Practice …, 2017 - Elsevier
Essentials• Inhibition of tumor cell trans‐endothelial migration inhibits metastasis formation.•
Low molecular weight heparin (LMWH)‐mediated endothelial barrier protection was …

Heparin as an inhibitor of cancer progression

L Borsig - Progress in molecular biology and translational …, 2010 - Elsevier
Heparin is frequently used in the treatment of cancer-associated thromboembolism.
Accumulating clinical evidence indicates that cancer patients treated with unfractionated and …

Non-anti-coagulant heparins: a promising approach for prevention of tumor metastasis

M Kragh, F Loechel - International journal of oncology, 2005 - spandidos-publications.com
The metastatic spread of solid tumors is responsible for most cancer-related deaths, and
unfortunately no specific anti-metastatic therapy exists. Heparin is widely used in the clinic …