The synthesis of NAD (or NADP) from tryptophan involves a series of enzymes and the
formation of a number of intermediates which are collectively calledkynurenines.'In the late …

Tryptophan is metabolised primarily along the kynurenine pathway, of which two
components are now known to have marked effects on neurons in the central nervous …

Over the past 2 decades, a number of studies have demonstrated that amino acids act as
precursors for the biosynthesis of a variety of neuroactive compounds, including …

The essential amino acid tryptophan is not only a precursor of serotonin but is also
degraded to several other neuroactive compounds, including kynurenic acid, 3 …

The synthesis of (o-nitrobenzoyl)-,(/n-nitrobenzoyl)-, and (p-nitrobenzoyl) alanine (o-, m-,
and p-NBA), three new kynurenine analogues, and their evaluation as inhibitors of …

In mammalian cells, the essential amino acid tryptophan is degraded primarily by the
kynurenine pathway, a cascade of enzymatic steps containing several biologically active …

The metabolism of tryptophan mostly proceeds through the kynurenine pathway. The
biochemical reaction includes both an agonist (quinolinic acid) at the N-methyl-d-aspartate …

The kynurenine pathway (KP) of tryptophan metabolism has emerged in recent years as a
key regulator of the production of both neuroprotective (eg kynurenic and picolinic acid, and …

Kynurenate is an endogenous antagonist of the ionotropic glutamate receptors. It is
synthesized from kynurenine, a tryptophan metabolite, and a significant increase in its brain …

One pathway by which tryptophan is metabolized in the brain as well as in the periphery is
through cleavage of the indole ring to formylkynurenine and then kynurenine. Indoleamine …