Metastasis involves several distinct steps, including one in which the tumor cell, after entry
into the bloodstream, comes to rest in a capillary located at the distant site where a …

A study was made on the effect of warfarin-induced anticoagulation on the ability of KHT
sarcoma cells to metastasize in syngeneic C3H mice. This anticoagulant effectively reduced …

There is now considerable evidence that the blood coagulation system plays an important
role in the biology of malignant tumors. This evidence has been derived from a combination …

Inhibition of coagulation greatly limits cancer metastasis in many experimental models.
Cancer cells trigger coagulation, through expression of tissue factor or P‐selectin ligands …

It is widely accepted that the blood coagulation process represents a fine balance between
the activation and inhibition of selective serine proteinase within the coagulation system …

There is evidence that the coagulation mechanism plays a role in the development of
metastases and that anticoagulants, by interfering with the adherence of tumor cells to …

Multiple mechanisms are involved in the pathophysiology of thrombosis in cancer. It is highly
likely that, in an individual patient, a multifactorial etiology is operative. The three basic …

Hemostatic abnormalities are present in a majority of patients with metastatic cancer. These
abnormalities can be categorized as 1) increased platelet aggregation and activation, 2) …

Experimental and clinical studies have shown an anticancer effect of anticoagulant drugs.
The aim of this study is to review the mechanisms by which the common types of …

Pathogenesis of the prothrombotic state of cancer patients is due, at least in part, to the
ability of cancer cells to activate the coagulation system. Several complex and not fully …