The parent pyridine nucleotide NAD is the end product of oxidative tryptophan catabolism
via the kynurenine pathway. Indoleamine 2, 3-dioxygenase, the rate-limiting enzyme for this …

IFN-γ activation of mononuclear phagocytes significantly increases indoleamine 2, 3-
dioxygenase (IDO) and flux through the kynurenine pathway (KP). However, the effect of IDO …

The regulation of the expression of indoleamine 2, 3-dioxygenase (IDO) was studied in
cloned murine macrophages (MT2) and microglial (N11) cells. Both cell lines express IDO …

Astroglia provide essential metabolic and neurotropic support to cells within the CNS and
participate in the cellular immune response with microglia/macrophages following activation …

Indoleamine 2, 3-dioxygenase (IDO) and nitric oxide synthase (NOS) type II are induced in
macrophages by interferon (IFN)-γ and lipopolysaccharide (LPS). Nitric oxide has been …

We evaluated the synthesis of nitric oxide (NO) and of the neurotoxic kynurenine metabolites
3OH-kynurenine and quinolinic acid (QUIN) in interferon-γ (IFN-γ)-activated macrophages of …

Indoleamine 2, 3-dioxygenase (IDO) and nitric oxide synthase are part of the anti-tumor and
antimicrobial activities of mononuclear phagocytes induced by interferon-gamma (IFN …

In chronic granulomatous disease (CGD), defective phagocytic nicotinamide adenine
dinucleotide phosphate (NADPH) oxidase activity causes reduced superoxide anion (O2· ̄) …

We studied the effects of tryptophan (TRP) availability on the synthesis and release of nitric
oxide (NO) and tumor necrosis factor α (TNF-α) in interferon-γ (IFN-γ)-activated murine …

This article summarises studies supporting the proposal that induction of L-tryptophan (Trp)
degradation along the kynurenine pathway in human monocytes and macrophages by …