Targeted alterations in the nucleoprotein fibre of chromatin represent a major mechanism of
gene control in eukarya, and the aetiology of a large number of human pathological …

In eukaryotic cells, the DNA molecule is found in the form of a nucleoprotein complex named
chromatin. The basic unit of the chromatin is the nucleosome, which comprises 147 base …

Proper regulation of the chromatin landscape is essential for maintaining eukaryotic cell
identity and diverse cellular processes. The importance of the epigenome comes, in part …

Many phenotypic changes of eukaryotic cells due to changes in gene expression depend on
alterations in chromatin structure. Processes involved in the alteration of chromatin are …

Chromatin regulatory mechanisms play a major role in the control of gene expression
programs during normal development and are disrupted in specific disease states …

Chromatin-modulating agents as epigenetic anticancer drugs – ‘the die is cast’ × Close The
Infona portal uses cookies, ie strings of text saved by a browser on the user's device. The …

Recent years have seen major advances in elucidating the complexity of chromatin and its
role as an epigenetic regulator of gene expression in eukaryotes. We now have a basic …

Recent advances in the enzymology of transcription and chromatin regulation have led to
the discovery of proteins that play a prominent role in cell differentiation and the …

The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

The regulation of chromatin by epigenetic mechanisms plays a central role in gene
expression and is essential for development and maintenance of cell identity and function …