Histone acetylation correlates well with transcriptional activity, and histone
acetyltransferases (HATs) selectively regulate subsets of target genes by mechanisms that …

Transcriptional activators often require histone acetyltransferases (HATs) for full activity. The
common explanation is that activators directly recruit HATs to gene promoters to locally …

Gcn5p is a transcriptional coactivator required for correct expression of various genes in
yeast. Several transcriptional regulators, including Gcn5p, possess intrinsic histone …

Yeast and human ADA2 and GCN5 (y-and hADA2 and y-and hGCN5, respectively) have
been shown to potentiate transcription in vivo and may function as adaptors to bridge …

The coactivator/adaptor protein Gcn5 is a conserved histone acetyltransferase, which
functions as the catalytic subunit in multiple yeast transcriptional regulatory complexes. The …

Several previously known transcription cofactors have been demonstrated in vitro recently to
be histone acetyltransferases and deacetyltransferases, suggesting that remodeling of …

The histone acetyltransferase (HAT) GCN5 is the founding member for a family of chromatin
remodeling enzymes. GCN5 is the catalytic subunit of a large multi-subunit complex that …

Within chromatin, reversible acetylation of core histones is critical for transcriptional
activation of eukaryotic target genes. The recent identification of intrinsic histone …

Previous studies have shown that the transcriptional coactivator protein Gcn5 functions as a
catalytic histone acetyltransferase (HAT). In this work, we examine the roles of the Ada2 and …

In yeast, the conserved histone acetyltransferase (HAT) Gcn5 associates with Ada2 and
Ada3 to form the catalytic module of the ADA and SAGA transcriptional coactivator …