The interaction between malignant cell growth and the coagulation and fibrinolysis system
has been a well known phenomenon for decades. During recent years, this area of research …

Critical information on the nature of the coagulation-cancer interaction has been obtained
from a number of sources. In vitro/ex vivo sources of information include assays performed …

The association between cancer and activation of blood coagulation has been described
since Trousseau's time. The hypercoagulable state often encountered in cancer patients not …

Since the first report by Trousseau in 1865, several experimental and clinical studies have
established that activation of coagulation is common in cancer. However, the biochemical …

Development of cancer is associated with activation of blood coagulation. The results of
laboratory tests clearly demonstrate that fibrin formation and dissolution is continuously …

It is widely recognized that a strong correlation exists between cancer and aberrant
hemostasis. Patients with various types of cancers often develop thrombosis, a phenomenon …

Malignancy affects the hemostatic system and the hemostatic system affects malignancy. In
cancer patients there are a number of coagulation abnormalities which provide the …

Tumor associated coagulopathy is a complex phenomenon that has been the subject of
study for more than a century. Many mechanisms have been implicated in this process …

Idiopathic thrombosis often precedes the diagnosis of occult cancer by several years.
Whether hypercoagulability predisposes for malignancy or the converse holds true is an …

The purpose of this review is to demonstrate the potential for development of coagulation-
reactive drugs for experimental cancer treatment. Improved cancer outcome has been …