Chromatin structure has a pivotal role in the regulation of gene expression. Transcriptional
activation or the repression of a gene require the recruitment of multiple chromatin …

Two phenomena have long been observed to correlate with transcriptionally active
chromatin: increased histone acetylation and increased sensitivity to nucleases, including …

The importance of histones and chromatin structure in the regulation of eukaryotic gene
transcription has become much more widely accepted over the past few years. It has been …

Transcription of chromatin-packaged genes involves highly regulated changes in
nucleosomal structure that control DNA accessibility. Two systems that facilitate these …

It has become widely accepted that modification of nucleosome structure is an important
regulatory mechanism. The hypothesis that the acetylation of histones is involved in …

Chromatin disruption and modification are associated with transcriptional regulation by
diverse coactivators and corepressors. Here we discuss the possible structural basis and …

The number of chromatin modifying and remodeling complexes implicated in genome
control is growing faster than our understanding of the functional roles they play. We discuss …

The assembly of eukaryotic DNA into folded nucleosomal arrays has drastic consequences
for many nuclear processes that require access to the DNA sequence, including RNA …

Extensive studies in the past few years have begun to demonstrate that chromosome
structure plays a critical role in transcriptional regulation. Two highly conserved mechanisms …

A role for histone modifications in transcription processes and the remodeling of chromatin
structure has been established. This review highlights the recent advances made in studies …